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GET1 protein (Naumovozyma castellii) - STRING interaction network
"GET1" - Golgi to ER traffic protein 1 in Naumovozyma castellii
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
GET1Golgi to ER traffic protein 1; Required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER (235 aa)    
Predicted Functional Partners:
GET3
ATPase GET3; ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] (351 aa)
     
 
  0.989
GET2
Golgi to ER traffic protein 2; Required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER (271 aa)
       
 
  0.931
XP_003676869.1
Uncharacterized protein; Ancestral locus Anc_6.57 (316 aa)
       
 
  0.927
XP_003674423.1
ER lumen protein-retaining receptor; Ancestral locus Anc_7.479 (218 aa)
           
  0.927
XP_003675825.1
Uncharacterized protein; Ancestral locus Anc_3.65 (213 aa)
       
 
  0.906
XP_003676213.1
Uncharacterized protein; Ancestral locus Anc_6.62; Belongs to the synaptobrevin family (188 aa)
     
 
  0.713
XP_003673363.1
Uncharacterized protein; Ancestral locus Anc_2.421; Belongs to the syntaxin family (377 aa)
       
 
  0.701
XP_003677588.1
ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER) (266 aa)
       
 
  0.628
XP_003678451.1
Uncharacterized protein; Ancestral locus Anc_4.230 (479 aa)
       
 
  0.623
XP_003677743.1
Uncharacterized protein; Ancestral locus Anc_6.21 (338 aa)
       
 
  0.610
Your Current Organism:
Naumovozyma castellii
NCBI taxonomy Id: 27288
Other names: AS 2.2404, ATCC 76901, CBS 4309, CCRC 22586, DBVPG 6298, N. castellii, NRRL Y-12630, Naumovia castellii, Naumovozyma castellii, Naumovozyma castellii Kurtzman 2008, Saccharomyces castellii, Saccharomyces castellii Capriotti
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