STRINGSTRING
PIF1 protein (Naumovozyma castellii) - STRING interaction network
"PIF1" - ATP-dependent DNA helicase PIF1 in Naumovozyma castellii
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5’-3’ DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (870 aa)    
Predicted Functional Partners:
XP_003676086.1
Uncharacterized protein; Ancestral locus Anc_5.75 (1301 aa)
   
 
  0.967
XP_003674373.1
DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays (392 aa)
   
 
  0.926
XP_003678210.1
Uncharacterized protein; Ancestral locus Anc_3.401 (2374 aa)
     
 
  0.876
XP_003678139.1
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand (259 aa)
   
 
  0.876
XP_003673008.1
Uncharacterized protein; Ancestral locus Anc_1.79 (1232 aa)
     
 
  0.866
XP_003677940.1
Uncharacterized protein; Ancestral locus Anc_5.575 (451 aa)
     
 
  0.851
XP_003673883.1
Uncharacterized protein; Ancestral locus Anc_1.274 (1147 aa)
     
 
  0.829
XP_003675494.1
Serine/threonine-protein kinase RAD53; Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5 (799 aa)
     
 
  0.816
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a [...] (379 aa)
     
 
  0.815
XP_003675977.1
Uncharacterized protein; Ancestral locus Anc_2.56 (908 aa)
       
 
  0.802
Your Current Organism:
Naumovozyma castellii
NCBI taxonomy Id: 27288
Other names: AS 2.2404, ATCC 76901, CBS 4309, CCRC 22586, DBVPG 6298, N. castellii, NRRL Y-12630, Naumovia castellii, Naumovozyma castellii, Naumovozyma castellii Kurtzman 2008, Saccharomyces castellii, Saccharomyces castellii Capriotti
Server load: low (23%) [HD]