STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bioYBioY family protein; Central protein that confers the ability to take up biotin on E.coli; while biotin transport requires BioM at very low (pM) concentrations at higher (nM) concentrations expression of BioY alone suffices for uptake. (190 aa)    
Predicted Functional Partners:
cbiQ3
Cobalt ABC transporter, permease protein CbiQ-3; Probably involved in biotin uptake, although complementation experiments in E.coli do not indicate a clear role.
 
 0.999
cbiO3
Cobalt ABC transporter, ATP-binding protein CbiO-3; Required for biotin uptake under very low (pM) biotin concentrations but not under higher (nM) concentrations.
 
 
 0.999
bioD
Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
  
  
 0.882
cbiQ1
Cobalt ABC transporter, permease protein CbiQ-1; Part of the energy-coupling factor (ECF) transporter complex NikMNQO involved in nickel import. The complex confers nickel uptake upon expression in E.coli; can also transport cobalt with a very low affinity.
  
 
 0.848
bioF
8-amino-7-oxononanoate synthase.
  
  
 0.778
bioA
Adenosylmethionine--8-amino-7-oxononanoate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
  
 0.773
cbiO2
Cobalt ABC transporter, ATP-binding protein CbiO-2; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity. Presumably responsible for energy coupling to the transport system.
   
 
 0.751
cbiQ2
Cobalt ABC transporter, permease protein CbiQ-2; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity; Belongs to the CbiQ family.
  
 
 0.705
dapA
Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
     
 0.652
birA1
biotin--[acetyl-CoA-carboxylase] ligase-1.
 
   
 0.602
Your Current Organism:
Rhodobacter capsulatus
NCBI taxonomy Id: 272942
Other names: R. capsulatus SB 1003, Rhodobacter capsulatus SB 1003
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