node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RSP_0403 | hisA | RSP_0403 | RSP_2243 | IMG reference gene:2512955413; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; IMG reference gene:2512954173; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.514 |
RSP_0403 | hisC | RSP_0403 | RSP_2284 | IMG reference gene:2512955413; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. | IMG reference gene:2512954218; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.428 |
RSP_0403 | hisD1 | RSP_0403 | RSP_0632 | IMG reference gene:2512955413; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.923 |
RSP_0403 | hisF | RSP_0403 | RSP_2242 | IMG reference gene:2512955413; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.422 |
RSP_0403 | hisG | RSP_0403 | RSP_3549 | IMG reference gene:2512955413; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.511 |
RSP_1984 | hisA | RSP_1984 | RSP_2243 | IMG reference gene:2512953900; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; truncated by 14 aa. | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; IMG reference gene:2512954173; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.915 |
RSP_1984 | hisB | RSP_1984 | RSP_2246 | IMG reference gene:2512953900; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; truncated by 14 aa. | IMG reference gene:2512954176; PFAM: Imidazoleglycerol-phosphate dehydratase. | 0.995 |
RSP_1984 | hisC | RSP_1984 | RSP_2284 | IMG reference gene:2512953900; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; truncated by 14 aa. | IMG reference gene:2512954218; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.925 |
RSP_1984 | hisD1 | RSP_1984 | RSP_0632 | IMG reference gene:2512953900; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; truncated by 14 aa. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.974 |
RSP_1984 | hisE | RSP_1984 | RSP_2241 | IMG reference gene:2512953900; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; truncated by 14 aa. | IMG reference gene:2512954171; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase. | 0.872 |
RSP_1984 | hisF | RSP_1984 | RSP_2242 | IMG reference gene:2512953900; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; truncated by 14 aa. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.932 |
RSP_1984 | hisG | RSP_1984 | RSP_3549 | IMG reference gene:2512953900; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; truncated by 14 aa. | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.929 |
RSP_1984 | hisH | RSP_1984 | RSP_2245 | IMG reference gene:2512953900; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; truncated by 14 aa. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.950 |
RSP_1984 | hisI | RSP_1984 | RSP_2627 | IMG reference gene:2512953900; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; truncated by 14 aa. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.928 |
hisA | RSP_0403 | RSP_2243 | RSP_0403 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; IMG reference gene:2512954173; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | IMG reference gene:2512955413; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. | 0.514 |
hisA | RSP_1984 | RSP_2243 | RSP_1984 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; IMG reference gene:2512954173; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | IMG reference gene:2512953900; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; truncated by 14 aa. | 0.915 |
hisA | hisB | RSP_2243 | RSP_2246 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; IMG reference gene:2512954173; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | IMG reference gene:2512954176; PFAM: Imidazoleglycerol-phosphate dehydratase. | 0.991 |
hisA | hisC | RSP_2243 | RSP_2284 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; IMG reference gene:2512954173; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | IMG reference gene:2512954218; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.931 |
hisA | hisD1 | RSP_2243 | RSP_0632 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; IMG reference gene:2512954173; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.988 |
hisA | hisE | RSP_2243 | RSP_2241 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; IMG reference gene:2512954173; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | IMG reference gene:2512954171; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase. | 0.992 |