STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fnrLCrp-Fnr regulatory protein (FnrL); Anaerobic regulatory protein; transcriptional activator of hemA. Appears to regulate other genes. (248 aa)    
Predicted Functional Partners:
hemZ
Coproporphyrinogen III oxidase; Involved in the heme and chlorophyll biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX; Belongs to the anaerobic coproporphyrinogen-III oxidase family.
 
  
 0.907
prrA
PrrA (RegA), Response regulator involved in oxygen regulation of photosynthesis genes; Member of the two-component regulatory system RegB/RegA. Involved in transactivating anaerobic expression of the photosynthetic apparatus. It is a transcriptional regulator that is responsible for activating expression of the puf, puh, and puc operons in response to a decrease in oxygen tension.
      
 0.827
ppsR
Transcriptional regulator, PpsR; IMG reference gene:2512955289; PFAM: Bacterial regulatory protein, Fis family; TIGRFAM: transcriptional regulator PpsR.
      
 0.822
RSP_0697
IMG reference gene:2512955718; PFAM: Universal stress protein family.
 
  
 0.800
prrB
Sensor histidine kinase PrrB (RegB); Member of the two-component regulatory system RegB/RegA. Involved in the positive regulation of photosynthesis gene expression in response to anaerobiosis. Also involved in positive regulation of the cbbI and cbbII Calvin cycle CO2 fixation operons, as well as in regulation of expression of genes involved in alternative CO2 fixation pathways. Phosphorylates RegA/PrrA.
   
 
 0.792
appA
IMG reference gene:2512953460; PFAM: Sensors of blue-light using FAD.
   
  
 0.777
hemN
Coproporphyrinogen III oxidase; Anaerobic transformation of coproporphyrinogen III into protoporphyrinogen IX. Dedicated to bacteriochlorophyll biosynthesis. Belongs to the anaerobic coproporphyrinogen-III oxidase family.
 
  
 0.761
ccoN
Cbb3-type cytochrome oxidase CcoN subunit; IMG reference gene:2512955717; PFAM: Cytochrome C and Quinol oxidase polypeptide I; TIGRFAM: cytochrome c oxidase, cbb3-type, subunit I; Belongs to the heme-copper respiratory oxidase family.
 
  
 0.757
dorS
IMG reference gene:2512956545; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; Hpt domain.
  
 
 0.750
nnrR
IMG reference gene:2512955337; PFAM: Bacterial regulatory proteins, crp family; Cyclic nucleotide-binding domain.
  
  
 0.748
Your Current Organism:
Rhodobacter sphaeroides 241
NCBI taxonomy Id: 272943
Other names: R. sphaeroides 2.4.1, Rhodobacter sphaeroides 2.4.1, Rhodobacter sphaeroides ATCC 17023, Rhodobacter sphaeroides ATH 2.4.1, Rhodobacter sphaeroides str. 2.4.1, Rhodobacter sphaeroides strain 2.4.1
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.