node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RSP_3550 | hisA | RSP_3550 | RSP_2243 | ATP phosphoribosyltransferase regulatory subunit; IMG reference gene:2512957060. | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; IMG reference gene:2512954173; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.934 |
RSP_3550 | hisB | RSP_3550 | RSP_2246 | ATP phosphoribosyltransferase regulatory subunit; IMG reference gene:2512957060. | IMG reference gene:2512954176; PFAM: Imidazoleglycerol-phosphate dehydratase. | 0.934 |
RSP_3550 | hisC | RSP_3550 | RSP_2284 | ATP phosphoribosyltransferase regulatory subunit; IMG reference gene:2512957060. | IMG reference gene:2512954218; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.845 |
RSP_3550 | hisD | RSP_3550 | RSP_2155 | ATP phosphoribosyltransferase regulatory subunit; IMG reference gene:2512957060. | IMG reference gene:2512954079; PFAM: Histidinol dehydrogenase; TIGRFAM: histidinol dehydrogenase. | 0.907 |
RSP_3550 | hisD1 | RSP_3550 | RSP_0632 | ATP phosphoribosyltransferase regulatory subunit; IMG reference gene:2512957060. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.906 |
RSP_3550 | hisE | RSP_3550 | RSP_2241 | ATP phosphoribosyltransferase regulatory subunit; IMG reference gene:2512957060. | IMG reference gene:2512954171; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase. | 0.992 |
RSP_3550 | hisF | RSP_3550 | RSP_2242 | ATP phosphoribosyltransferase regulatory subunit; IMG reference gene:2512957060. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.933 |
RSP_3550 | hisG | RSP_3550 | RSP_3549 | ATP phosphoribosyltransferase regulatory subunit; IMG reference gene:2512957060. | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.999 |
RSP_3550 | hisH | RSP_3550 | RSP_2245 | ATP phosphoribosyltransferase regulatory subunit; IMG reference gene:2512957060. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.932 |
RSP_3550 | hisI | RSP_3550 | RSP_2627 | ATP phosphoribosyltransferase regulatory subunit; IMG reference gene:2512957060. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.931 |
hisA | RSP_3550 | RSP_2243 | RSP_3550 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; IMG reference gene:2512954173; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase regulatory subunit; IMG reference gene:2512957060. | 0.934 |
hisA | hisB | RSP_2243 | RSP_2246 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; IMG reference gene:2512954173; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | IMG reference gene:2512954176; PFAM: Imidazoleglycerol-phosphate dehydratase. | 0.991 |
hisA | hisC | RSP_2243 | RSP_2284 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; IMG reference gene:2512954173; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | IMG reference gene:2512954218; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.931 |
hisA | hisD | RSP_2243 | RSP_2155 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; IMG reference gene:2512954173; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | IMG reference gene:2512954079; PFAM: Histidinol dehydrogenase; TIGRFAM: histidinol dehydrogenase. | 0.976 |
hisA | hisD1 | RSP_2243 | RSP_0632 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; IMG reference gene:2512954173; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.988 |
hisA | hisE | RSP_2243 | RSP_2241 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; IMG reference gene:2512954173; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | IMG reference gene:2512954171; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase. | 0.992 |
hisA | hisF | RSP_2243 | RSP_2242 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; IMG reference gene:2512954173; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.997 |
hisA | hisG | RSP_2243 | RSP_3549 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; IMG reference gene:2512954173; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.953 |
hisA | hisH | RSP_2243 | RSP_2245 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; IMG reference gene:2512954173; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.999 |
hisA | hisI | RSP_2243 | RSP_2627 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; IMG reference gene:2512954173; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |