STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemA5-aminolevulinate synthase; IMG reference gene:2512954950; PFAM: Aminotransferase class I and II; TIGRFAM: 5-aminolevulinic acid synthase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (407 aa)    
Predicted Functional Partners:
hemB
IMG reference gene:2512954756; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
  
 
 0.976
soxA
Putative sarcosine oxidase, alpha subunit; IMG reference gene:2512954634; PFAM: Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; TIGRFAM: sarcosine oxidase, alpha subunit family, heterotetrameric form; Belongs to the GcvT family.
  
 0.959
RSP_1569
Glutamate-1-semialdehyde 2,1-aminomutase; IMG reference gene:2512953464; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
     
 0.954
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
  
 
 0.946
kbl
2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
  
  
0.930
SHMT
Serine hydroxymethyltransferase protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.925
RSP_1448
L-threonine aldolase; IMG reference gene:2512953339; PFAM: Beta-eliminating lyase.
     
 0.908
RSP_2302
L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde.
     
 0.908
soxD
IMG reference gene:2512954633; PFAM: Sarcosine oxidase, delta subunit family; TIGRFAM: sarcosine oxidase, delta subunit family, heterotetrameric form.
   
 
  0.907
hemT
5-aminolevulinate synthase; IMG reference gene:2512956527; PFAM: Aminotransferase class I and II; TIGRFAM: 5-aminolevulinic acid synthase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
  
 
0.907
Your Current Organism:
Rhodobacter sphaeroides 241
NCBI taxonomy Id: 272943
Other names: R. sphaeroides 2.4.1, Rhodobacter sphaeroides 2.4.1, Rhodobacter sphaeroides ATCC 17023, Rhodobacter sphaeroides ATH 2.4.1, Rhodobacter sphaeroides str. 2.4.1, Rhodobacter sphaeroides strain 2.4.1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.