STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RP063HESB PROTEIN (hesB1); Belongs to the HesB/IscA family. (110 aa)    
Predicted Functional Partners:
RP201
Unknown; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.
  
 
 0.880
RP485
NIFU PROTEIN (nifU); A scaffold on which IscS assembles Fe-S clusters. Subsequently gives the nascent cluster to other proteins. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters (By similarity). Belongs to the NifU family.
  
  
 0.861
RP745
GLUTAREDOXIN-LIKE PROTEIN GRLA (grxC2); Belongs to the glutaredoxin family. Monothiol subfamily.
  
 0.856
RP667
Unknown.
  
 
 0.765
RP464
Unknown; Belongs to the GcvT family.
 
 
 0.655
RP486
NIFS PROTEIN HOMOLOG (spl1); Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
  
  
 0.654
RP487
NIFS PROTEIN HOMOLOG (spl1).
  
  
 0.654
RP064
DEOXYGUANOSINETRIPHOSPHATE TRIPHOSPHOHYDROLASE (dgtP); Belongs to the dGTPase family. Type 2 subfamily.
     
 0.636
RP529
PEPTIDE CHAIN RELEASE FACTOR 1 (prfA); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
     
 0.624
RP199
ADRENODOXIN PRECURSOR (adx1); Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; Belongs to the adrenodoxin/putidaredoxin family.
  
 
 0.592
Your Current Organism:
Rickettsia prowazekii
NCBI taxonomy Id: 272947
Other names: R. prowazekii str. Madrid E, Rickettsia prowazekii str. Madrid E, Rickettsia prowazekii strain Madrid E
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.