node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RP048 | RP079 | gene:17555131 | gene:17555162 | 60 KD INNER-MEMBRANE PROTEIN (yidC); Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | PROTEIN-EXPORT MEMBRANE PROTEIN SECG (secG); Involved in protein export. Participates in an early event of protein translocation (By similarity); Belongs to the SecG family. | 0.987 |
RP048 | RP114 | gene:17555131 | gene:17555197 | 60 KD INNER-MEMBRANE PROTEIN (yidC); Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | PROTEIN-EXPORT MEMBRANE PROTEIN SECF (secF); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.915 |
RP048 | RP134 | gene:17555131 | gene:17555217 | 60 KD INNER-MEMBRANE PROTEIN (yidC); Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | Unknown (secE); Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. | 0.980 |
RP048 | RP418 | gene:17555131 | gene:17555498 | 60 KD INNER-MEMBRANE PROTEIN (yidC); Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN (pheT); Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.741 |
RP048 | RP575 | gene:17555131 | gene:17555655 | 60 KD INNER-MEMBRANE PROTEIN (yidC); Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | PREPROTEIN TRANSLOCASE SECA SUBUNIT (secA); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. | 0.951 |
RP048 | RP585 | gene:17555131 | gene:17555665 | 60 KD INNER-MEMBRANE PROTEIN (yidC); Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | Unknown; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. | 0.975 |
RP048 | RP586 | gene:17555131 | gene:17555666 | 60 KD INNER-MEMBRANE PROTEIN (yidC); Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | PROTEIN-EXPORT MEMBRANE PROTEIN SECD (secD); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.958 |
RP048 | RP639 | gene:17555131 | gene:17555716 | 60 KD INNER-MEMBRANE PROTEIN (yidC); Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | PREPROTEIN TRANSLOCASE SECY SUBUNIT (secY); The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.990 |
RP079 | RP048 | gene:17555162 | gene:17555131 | PROTEIN-EXPORT MEMBRANE PROTEIN SECG (secG); Involved in protein export. Participates in an early event of protein translocation (By similarity); Belongs to the SecG family. | 60 KD INNER-MEMBRANE PROTEIN (yidC); Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.987 |
RP079 | RP114 | gene:17555162 | gene:17555197 | PROTEIN-EXPORT MEMBRANE PROTEIN SECG (secG); Involved in protein export. Participates in an early event of protein translocation (By similarity); Belongs to the SecG family. | PROTEIN-EXPORT MEMBRANE PROTEIN SECF (secF); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.808 |
RP079 | RP134 | gene:17555162 | gene:17555217 | PROTEIN-EXPORT MEMBRANE PROTEIN SECG (secG); Involved in protein export. Participates in an early event of protein translocation (By similarity); Belongs to the SecG family. | Unknown (secE); Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. | 0.999 |
RP079 | RP418 | gene:17555162 | gene:17555498 | PROTEIN-EXPORT MEMBRANE PROTEIN SECG (secG); Involved in protein export. Participates in an early event of protein translocation (By similarity); Belongs to the SecG family. | PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN (pheT); Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.692 |
RP079 | RP575 | gene:17555162 | gene:17555655 | PROTEIN-EXPORT MEMBRANE PROTEIN SECG (secG); Involved in protein export. Participates in an early event of protein translocation (By similarity); Belongs to the SecG family. | PREPROTEIN TRANSLOCASE SECA SUBUNIT (secA); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. | 0.999 |
RP079 | RP585 | gene:17555162 | gene:17555665 | PROTEIN-EXPORT MEMBRANE PROTEIN SECG (secG); Involved in protein export. Participates in an early event of protein translocation (By similarity); Belongs to the SecG family. | Unknown; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. | 0.985 |
RP079 | RP586 | gene:17555162 | gene:17555666 | PROTEIN-EXPORT MEMBRANE PROTEIN SECG (secG); Involved in protein export. Participates in an early event of protein translocation (By similarity); Belongs to the SecG family. | PROTEIN-EXPORT MEMBRANE PROTEIN SECD (secD); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.973 |
RP079 | RP639 | gene:17555162 | gene:17555716 | PROTEIN-EXPORT MEMBRANE PROTEIN SECG (secG); Involved in protein export. Participates in an early event of protein translocation (By similarity); Belongs to the SecG family. | PREPROTEIN TRANSLOCASE SECY SUBUNIT (secY); The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.999 |
RP114 | RP048 | gene:17555197 | gene:17555131 | PROTEIN-EXPORT MEMBRANE PROTEIN SECF (secF); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 60 KD INNER-MEMBRANE PROTEIN (yidC); Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.915 |
RP114 | RP079 | gene:17555197 | gene:17555162 | PROTEIN-EXPORT MEMBRANE PROTEIN SECF (secF); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | PROTEIN-EXPORT MEMBRANE PROTEIN SECG (secG); Involved in protein export. Participates in an early event of protein translocation (By similarity); Belongs to the SecG family. | 0.808 |
RP114 | RP134 | gene:17555197 | gene:17555217 | PROTEIN-EXPORT MEMBRANE PROTEIN SECF (secF); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | Unknown (secE); Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. | 0.913 |
RP114 | RP326 | gene:17555197 | gene:17555406 | PROTEIN-EXPORT MEMBRANE PROTEIN SECF (secF); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | DNA TOPOISOMERASE I (topA); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...] | 0.749 |