STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RP740HEMOLYSIN C (tlyC). (303 aa)    
Predicted Functional Partners:
RP741
Unknown; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
  
  
 0.882
RP819
Unknown; Could be a virulence factor; Belongs to the phospholipase D family.
  
  
 0.695
RP236
INVASION PROTEIN A (invA); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity). Preferentially hydrolyzes diadenosine penta-phosphate with ATP as one of the reaction products. Also able to hydrolyze diadenosine hexa-phosphate and diguanosine penta-phosphate. Has little or no activity on diadenosine tetra- and tri-phosphate, on diguanosine tetra- and tri-phosphate, on GDP-mannose, ADP-ribose, NADH and NAD(+); Bel [...]
     
 0.683
RP742
LIPOIC ACID SYNTHETASE (lipA); Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
       0.605
RP743
SERINE HYDROXYMETHYLTRANSFERASE (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
       0.604
RP704
CELL SURFACE ANTIGEN (sca5); The 120 kDa surface-exposed protein is a major structural protein which may play a role as a rickettsial virulence factor and/or immunogen during infection.
      
 0.591
RP294
GUANOSINE PENTAPHOSPHATE PHOSPHOHYDROLASE (gppA).
      
 0.587
RP418
PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN (pheT); Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
     
 0.587
RP555
HEMOLYSIN (tlyA).
     
 0.535
RP335
Unknown.
  
 
 0.524
Your Current Organism:
Rickettsia prowazekii
NCBI taxonomy Id: 272947
Other names: R. prowazekii str. Madrid E, Rickettsia prowazekii str. Madrid E, Rickettsia prowazekii strain Madrid E
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.