STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RP742LIPOIC ACID SYNTHETASE (lipA); Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (297 aa)    
Predicted Functional Partners:
RP876
PROBABLE LIPOATE-PROTEIN LIGASE B (lipB); Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
 
 0.997
RP743
SERINE HYDROXYMETHYLTRANSFERASE (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
  
 0.822
RP513
RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA CHAIN (nrdA); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
 
      0.644
RP741
Unknown; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
       0.630
RP620
2-ACYLGLYCEROPHOSPHOETHANOLAMINE ACYLTRANSFERASE (aas).
     
 0.613
RP740
HEMOLYSIN C (tlyC).
       0.605
RP744
Unknown; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
       0.571
RP745
GLUTAREDOXIN-LIKE PROTEIN GRLA (grxC2); Belongs to the glutaredoxin family. Monothiol subfamily.
     
 0.554
RP776
DNA POLYMERASE I (polA); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
      
 0.526
RP007
ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N- ACETYLGLUCOSAMINE O-ACYLTRANSFERASE (lpxA); Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
  
  
 0.518
Your Current Organism:
Rickettsia prowazekii
NCBI taxonomy Id: 272947
Other names: R. prowazekii str. Madrid E, Rickettsia prowazekii str. Madrid E, Rickettsia prowazekii strain Madrid E
Server load: medium (64%) [HD]