node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RP326 | RP539 | gene:17555406 | gene:17555619 | DNA TOPOISOMERASE I (topA); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...] | DELTA-AMINOLEVULINIC ACID DEHYDRATASE (hemB); Belongs to the ALAD family. | 0.690 |
RP326 | RP841 | gene:17555406 | gene:17555910 | DNA TOPOISOMERASE I (topA); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...] | 5-AMINOLEVULINIC ACID SYNTHASE (hemA); Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.640 |
RP346 | RP466 | gene:17555426 | gene:17555546 | CYTOCHROME C OXIDASE ASSEMBLY FACTOR (ctaB); Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. | PORPHOBILINOGEN DEAMINASE (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.703 |
RP346 | RP620 | gene:17555426 | gene:17555699 | CYTOCHROME C OXIDASE ASSEMBLY FACTOR (ctaB); Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. | 2-ACYLGLYCEROPHOSPHOETHANOLAMINE ACYLTRANSFERASE (aas). | 0.569 |
RP346 | RP680 | gene:17555426 | gene:17555757 | CYTOCHROME C OXIDASE ASSEMBLY FACTOR (ctaB); Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. | UBIQUINONE/MENAQUINONE BIOSYNTHESIS METHLYTRANSFERASE UBIE (ubiE); Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.668 |
RP346 | RP686 | gene:17555426 | gene:17555763 | CYTOCHROME C OXIDASE ASSEMBLY FACTOR (ctaB); Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. | 4-HYDROXYBENZOATE OCTAPRENYLTRANSFERASE (ubiA); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.782 |
RP346 | RP841 | gene:17555426 | gene:17555910 | CYTOCHROME C OXIDASE ASSEMBLY FACTOR (ctaB); Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. | 5-AMINOLEVULINIC ACID SYNTHASE (hemA); Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.669 |
RP346 | RP882 | gene:17555426 | gene:17555951 | CYTOCHROME C OXIDASE ASSEMBLY FACTOR (ctaB); Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. | COPROPORPHYRINOGEN III OXIDASE PRECURSOR (hemF); Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.752 |
RP466 | RP346 | gene:17555546 | gene:17555426 | PORPHOBILINOGEN DEAMINASE (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | CYTOCHROME C OXIDASE ASSEMBLY FACTOR (ctaB); Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. | 0.703 |
RP466 | RP539 | gene:17555546 | gene:17555619 | PORPHOBILINOGEN DEAMINASE (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | DELTA-AMINOLEVULINIC ACID DEHYDRATASE (hemB); Belongs to the ALAD family. | 0.997 |
RP466 | RP680 | gene:17555546 | gene:17555757 | PORPHOBILINOGEN DEAMINASE (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | UBIQUINONE/MENAQUINONE BIOSYNTHESIS METHLYTRANSFERASE UBIE (ubiE); Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.680 |
RP466 | RP686 | gene:17555546 | gene:17555763 | PORPHOBILINOGEN DEAMINASE (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 4-HYDROXYBENZOATE OCTAPRENYLTRANSFERASE (ubiA); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.776 |
RP466 | RP743 | gene:17555546 | gene:17555813 | PORPHOBILINOGEN DEAMINASE (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | SERINE HYDROXYMETHYLTRANSFERASE (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.535 |
RP466 | RP841 | gene:17555546 | gene:17555910 | PORPHOBILINOGEN DEAMINASE (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 5-AMINOLEVULINIC ACID SYNTHASE (hemA); Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.756 |
RP466 | RP882 | gene:17555546 | gene:17555951 | PORPHOBILINOGEN DEAMINASE (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | COPROPORPHYRINOGEN III OXIDASE PRECURSOR (hemF); Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.826 |
RP539 | RP326 | gene:17555619 | gene:17555406 | DELTA-AMINOLEVULINIC ACID DEHYDRATASE (hemB); Belongs to the ALAD family. | DNA TOPOISOMERASE I (topA); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...] | 0.690 |
RP539 | RP466 | gene:17555619 | gene:17555546 | DELTA-AMINOLEVULINIC ACID DEHYDRATASE (hemB); Belongs to the ALAD family. | PORPHOBILINOGEN DEAMINASE (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.997 |
RP539 | RP686 | gene:17555619 | gene:17555763 | DELTA-AMINOLEVULINIC ACID DEHYDRATASE (hemB); Belongs to the ALAD family. | 4-HYDROXYBENZOATE OCTAPRENYLTRANSFERASE (ubiA); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.448 |
RP539 | RP841 | gene:17555619 | gene:17555910 | DELTA-AMINOLEVULINIC ACID DEHYDRATASE (hemB); Belongs to the ALAD family. | 5-AMINOLEVULINIC ACID SYNTHASE (hemA); Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.944 |
RP539 | RP882 | gene:17555619 | gene:17555951 | DELTA-AMINOLEVULINIC ACID DEHYDRATASE (hemB); Belongs to the ALAD family. | COPROPORPHYRINOGEN III OXIDASE PRECURSOR (hemF); Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.566 |