STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
lysMTranscriptional regulator; In the absence or at low concentrations of lysine, activates the biosynthesis of this amino acid via the alpha-aminoadipate (AAA) pathway. (142 aa)    
Predicted Functional Partners:
argB
Acetylglutamate kinase (argB); Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily.
     
 0.929
argC
N-acetyl-gamma-glutamyl-phosphate reductase (argC); Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
     
 0.928
lysW
Conserved hypothetical protein; Carrier protein that bears the covalently bound substrates for arginine and lysine biosynthesis; bound L-glutamate is sequentially converted to L-ornithine, while bound alpha-aminoadipate (AAA) is sequentially converted to L-lysine.
     
 0.838
lysK
Conserved hypothetical protein; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
 
     0.687
gabT-2
4-aminobutyrate aminotransferase (gabT-2); Amino Acid Biosynthesis; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
     
 0.657
rimK-1
Ribosomal protein S6 modification protein (rimK-1); Catalyzes the ATP-dependent formation of a covalent bond between the amino group of alpha-aminoadipate (AAA) and the gamma- carboxyl group of the C-terminal glutamate residue in LysW. Belongs to the RimK family. LysX subfamily.
     
 0.656
lrs14
Transcriptional regulator Lrs14; Acts in transcription regulation. Binds to multiple sequences in its own promoter.
      
 0.654
argD
Acetylornithine aminotransferase (argD); Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.
     
 0.636
SSO2233
Hypothetical protein.
 
  
 0.631
uppS
Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
       0.629
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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