STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
SSO0259Conserved hypothetical protein; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. (255 aa)    
Predicted Functional Partners:
ubiA-2
4-hydroxybenzoate octaprenyltransferase, putative (ubiA-2); Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. Cannot use other prenyl donors, i.e. farnesyl diphosphate (FPP) and phytyl diphosphate. Moreover, 4-hydroxybenzoate, 1,4-dihydroxy 2-naphthoate, homogentisate, and alpha-glycerophosphate do not function as prenyl acceptor substrates.
 
  
 0.987
gldA
Glycerol-1-phosphate dehydrogenase (gldA); Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
     
 0.950
SSO0260
Conserved hypothetical protein.
       0.852
SSO0261
Conserved hypothetical protein; Similarity with APE0663.
       0.663
tpiA
Triosephosphate isomerase (tpiA); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
 
   
 0.551
SSO6503
Conserved hypothetical protein; Belongs to the UPF0147 family.
 
     0.424
SSO0814
Conserved hypothetical protein.
  
     0.423
SSO1901
Hypothetical protein.
  
     0.415
topA
DNA topoisomerase I family A (topA); Replication and Repair.
  
    0.409
purL
Phosphoribosylformylglycinamidine synthase II (FGAM synthase II) (purL); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL [...]
 
     0.401
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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