node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dph2 | EF-2 | SSO0293 | SSO0728 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Elongation factor 2 (EF-2); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. | 0.971 |
Dph2 | cbiG | SSO0293 | SSO0129 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Cobalamin biosynthesis protein G (cbiG); Similar to MTH1408 (Methanobacterium thermoautotrophicum); Cofactor Biosynthesis. | 0.653 |
Dph2 | cbiG-like | SSO0293 | SSO2297 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Cobalamin biosynthesis protein G homolog, putative (cbiG-like); Cofactor Biosynthesis. | 0.669 |
Dph2 | csl4 | SSO0293 | SSO0292 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Conserved hypothetical protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. | 0.866 |
Dph2 | dphB | SSO0293 | SSO0953 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Diphthine synthase, hypothetical; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.862 |
Dph2 | hisC | SSO0293 | SSO0592 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Histidinol-phosphate aminotransferase (hisC); Amino Acid Biosynthesis, Histidine. | 0.662 |
Dph2 | rpl10E | SSO0293 | SSO0294 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | LSU ribosomal protein L10E (rpl10E); Translation, Ribosomal Proteins; Belongs to the universal ribosomal protein uL16 family. | 0.947 |
Dph2 | rpoL | SSO0293 | SSO5577 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | DNA-directed RNA polymerase, subunit L (rpoL); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.900 |
Dph2 | rpoM-1 | SSO0293 | SSO0291 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | DNA-directed RNA polymerase, subunit M (rpoM-1); Possible in-frame shift with SSO5576. Similar to carboxy-end of RPOM_SULAC, but most other thermophilic genes are the same size; Transcription, RNA polymerase and transcription factors; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. | 0.883 |
Dph2 | rpoM-like | SSO0293 | SSO5576 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | DNA-directed RNA polymerase, putative subunit M (rpoM-like); Possible in-frame shift with SSO0291. Similar to amino-end of RPOM_SULAC; Transcription, RNA polymerase and transcription factors. | 0.810 |
EF-2 | Dph2 | SSO0728 | SSO0293 | Elongation factor 2 (EF-2); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.971 |
EF-2 | dphB | SSO0728 | SSO0953 | Elongation factor 2 (EF-2); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. | Diphthine synthase, hypothetical; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.987 |
EF-2 | rpl10E | SSO0728 | SSO0294 | Elongation factor 2 (EF-2); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. | LSU ribosomal protein L10E (rpl10E); Translation, Ribosomal Proteins; Belongs to the universal ribosomal protein uL16 family. | 0.999 |
cbiG | Dph2 | SSO0129 | SSO0293 | Cobalamin biosynthesis protein G (cbiG); Similar to MTH1408 (Methanobacterium thermoautotrophicum); Cofactor Biosynthesis. | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.653 |
cbiG | cbiG-like | SSO0129 | SSO2297 | Cobalamin biosynthesis protein G (cbiG); Similar to MTH1408 (Methanobacterium thermoautotrophicum); Cofactor Biosynthesis. | Cobalamin biosynthesis protein G homolog, putative (cbiG-like); Cofactor Biosynthesis. | 0.900 |
cbiG | hisC | SSO0129 | SSO0592 | Cobalamin biosynthesis protein G (cbiG); Similar to MTH1408 (Methanobacterium thermoautotrophicum); Cofactor Biosynthesis. | Histidinol-phosphate aminotransferase (hisC); Amino Acid Biosynthesis, Histidine. | 0.737 |
cbiG-like | Dph2 | SSO2297 | SSO0293 | Cobalamin biosynthesis protein G homolog, putative (cbiG-like); Cofactor Biosynthesis. | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.669 |
cbiG-like | cbiG | SSO2297 | SSO0129 | Cobalamin biosynthesis protein G homolog, putative (cbiG-like); Cofactor Biosynthesis. | Cobalamin biosynthesis protein G (cbiG); Similar to MTH1408 (Methanobacterium thermoautotrophicum); Cofactor Biosynthesis. | 0.900 |
cbiG-like | hisC | SSO2297 | SSO0592 | Cobalamin biosynthesis protein G homolog, putative (cbiG-like); Cofactor Biosynthesis. | Histidinol-phosphate aminotransferase (hisC); Amino Acid Biosynthesis, Histidine. | 0.741 |
csl4 | Dph2 | SSO0292 | SSO0293 | Conserved hypothetical protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.866 |