node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | SSO0594 | SSO0596 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Amino Acid Biosynthesis, Histidine. | Imidazoleglycerol-phosphate dehydratase (hisB); Amino Acid Biosynthesis, Histidine. | 0.999 |
hisA | hisC | SSO0594 | SSO0592 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Amino Acid Biosynthesis, Histidine. | Histidinol-phosphate aminotransferase (hisC); Amino Acid Biosynthesis, Histidine. | 0.988 |
hisA | hisC-like | SSO0594 | SSO0448 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Amino Acid Biosynthesis, Histidine. | Histidinol-phosphate aminotransferase, putative (hisC-like); Amino Acid Biosynthesis, Histidine. | 0.922 |
hisA | hisD | SSO0594 | SSO0599 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Amino Acid Biosynthesis, Histidine. | Histidinol dehydrogenase (HDH) (hisD); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisA | hisE | SSO0594 | SSO6223 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Amino Acid Biosynthesis, Histidine. | Phosphoribosyl-ATP cyclohydrolase (hisE); Amino Acid Biosynthesis. | 0.999 |
hisA | hisF | SSO0594 | SSO0597 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Amino Acid Biosynthesis, Histidine. | Imidazoleglycerol-phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.999 |
hisA | hisG | SSO0594 | SSO0593 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Amino Acid Biosynthesis, Histidine. | ATP phosphoribosyl transferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.999 |
hisA | hisH | SSO0594 | SSO0600 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Amino Acid Biosynthesis, Histidine. | Amidotransferase hisH (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.999 |
hisA | hisI | SSO0594 | SSO6227 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Amino Acid Biosynthesis, Histidine. | Phosphoribosyl-AMP cyclohydrolase (hisI); Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisB | hisA | SSO0596 | SSO0594 | Imidazoleglycerol-phosphate dehydratase (hisB); Amino Acid Biosynthesis, Histidine. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Amino Acid Biosynthesis, Histidine. | 0.999 |
hisB | hisC | SSO0596 | SSO0592 | Imidazoleglycerol-phosphate dehydratase (hisB); Amino Acid Biosynthesis, Histidine. | Histidinol-phosphate aminotransferase (hisC); Amino Acid Biosynthesis, Histidine. | 0.999 |
hisB | hisC-like | SSO0596 | SSO0448 | Imidazoleglycerol-phosphate dehydratase (hisB); Amino Acid Biosynthesis, Histidine. | Histidinol-phosphate aminotransferase, putative (hisC-like); Amino Acid Biosynthesis, Histidine. | 0.937 |
hisB | hisD | SSO0596 | SSO0599 | Imidazoleglycerol-phosphate dehydratase (hisB); Amino Acid Biosynthesis, Histidine. | Histidinol dehydrogenase (HDH) (hisD); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisE | SSO0596 | SSO6223 | Imidazoleglycerol-phosphate dehydratase (hisB); Amino Acid Biosynthesis, Histidine. | Phosphoribosyl-ATP cyclohydrolase (hisE); Amino Acid Biosynthesis. | 0.999 |
hisB | hisF | SSO0596 | SSO0597 | Imidazoleglycerol-phosphate dehydratase (hisB); Amino Acid Biosynthesis, Histidine. | Imidazoleglycerol-phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.999 |
hisB | hisG | SSO0596 | SSO0593 | Imidazoleglycerol-phosphate dehydratase (hisB); Amino Acid Biosynthesis, Histidine. | ATP phosphoribosyl transferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.999 |
hisB | hisH | SSO0596 | SSO0600 | Imidazoleglycerol-phosphate dehydratase (hisB); Amino Acid Biosynthesis, Histidine. | Amidotransferase hisH (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.999 |
hisB | hisI | SSO0596 | SSO6227 | Imidazoleglycerol-phosphate dehydratase (hisB); Amino Acid Biosynthesis, Histidine. | Phosphoribosyl-AMP cyclohydrolase (hisI); Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisC | hisA | SSO0592 | SSO0594 | Histidinol-phosphate aminotransferase (hisC); Amino Acid Biosynthesis, Histidine. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Amino Acid Biosynthesis, Histidine. | 0.988 |
hisC | hisB | SSO0592 | SSO0596 | Histidinol-phosphate aminotransferase (hisC); Amino Acid Biosynthesis, Histidine. | Imidazoleglycerol-phosphate dehydratase (hisB); Amino Acid Biosynthesis, Histidine. | 0.999 |