STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisDHistidinol dehydrogenase (HDH) (hisD); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (398 aa)    
Predicted Functional Partners:
hisC
Histidinol-phosphate aminotransferase (hisC); Amino Acid Biosynthesis, Histidine.
  
 0.999
hisG
ATP phosphoribosyl transferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
  
 0.999
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Amino Acid Biosynthesis, Histidine.
 
  
 0.999
hisB
Imidazoleglycerol-phosphate dehydratase (hisB); Amino Acid Biosynthesis, Histidine.
 
 0.999
hisF
Imidazoleglycerol-phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
  
 0.999
hisH
Amidotransferase hisH (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
 
  
 0.999
hisE
Phosphoribosyl-ATP cyclohydrolase (hisE); Amino Acid Biosynthesis.
 
  
 0.999
hisI
Phosphoribosyl-AMP cyclohydrolase (hisI); Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
  
 0.999
hisC-like
Histidinol-phosphate aminotransferase, putative (hisC-like); Amino Acid Biosynthesis, Histidine.
 
  
 0.932
purA
Adenylosuccinate synthase (IMP--aspartate ligase) (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
  
 0.777
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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