STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrBAspartate carbamoyltransferase catalytic chain (ATCase) (pyrB); Pyrimidines. (303 aa)    
Predicted Functional Partners:
pyrD
Dihydroorotate dehydrogenase (dihydroorotate oxidase) (DHOdehase) (pyrD); Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
 
  
 0.999
pyrC
Dihydroorotase (carbamoylaspartic dehydrase) (DHOase) (pyrC); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 0.999
pyrI
Aspartate carbamoyltransferase regulatory chain (pyrI); Involved in allosteric regulation of aspartate carbamoyltransferase.
 0.999
pyrE
Orotate phosphoribosyltransferase (OPRT) (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
 
  
 0.999
pyrF
Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPdcase) (pyrF); Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
  
  
 0.999
carA
Carbamoyl-phosphate synthase, small subunit (carA); Amino Acid Biosynthesis; Belongs to the CarA family.
 
 0.999
carB
Carbamoyl-phosphate synthase large subunit (carB); Amino Acid Biosynthesis, Pyrimidines.
 
 0.999
SSO0612
Hypothetical protein.
  
  
 0.998
purA
Adenylosuccinate synthase (IMP--aspartate ligase) (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.967
argG
Argininosuccinate synthetase (argG); Amino Acid Biosynthesis, Glutamate; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
  
 
 0.918
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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