STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
speESpermidine synthase; Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high- temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to various amine acceptors such as putrescine (1,4-diaminobutane), 1,3-diaminopropane, sym- norspermidine and spermidine. The biosynthesis of caldopentamine from norspermine has been also ob [...] (301 aa)    
Predicted Functional Partners:
SpeD
Conserved hypothetical protein; Specifically catalyzes the decarboxylation of L-arginine to agmatine. Is also able to decarboxylate L-canavanine, although less efficiently. Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
 
 
 0.995
speH
Conserved hypothetical protein; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine. Has no arginine decarboxylase (ArgDC) activity. Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
 
 
 0.995
snRNP-2
Small nuclear riboprotein protein (snRNP-2); Transcription, RNA modification.
  
  
 0.956
speB-1
Agmatinase (agmatine ureohydrolase) (speB-1); Amino Acid Biosynthesis, Aromatic amino acids; Belongs to the arginase family.
  
 
 0.955
speB-2
Agmatinase (agmatine ureohydrolase) (speB-2); Amino Acid Biosynthesis, Aromatic amino acids; Belongs to the arginase family.
  
 
 0.955
mtaP
5'-methylthioadenosine phosphorylase (mtaP); Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
  
 
 0.945
mtaP-2
5'-methylthioadenosine phosphorylase (mtaP); Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules. Cleaves inosine, guanosine, and adenosine with a better efficiency than MTA.
     
  0.900
rpl37E
LSU ribosomal protein L37E (rpl37E); Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family.
  
    0.863
snRNP-1
Small nuclear riboprotein protein (snRNP-1); Transcription, RNA modification.
  
  
 0.817
SSO0276
Hypothetical protein.
   
  
 0.816
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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