node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SSB | SSO0872 | SSO2364 | SSO0872 | Single-stranded DNA binding protein (SSB); Binds to ssDNA, binding approximately 5 nucleotides per monomer. Binding my be slightly cooperative. Inhibits the endonuclease activity of XPF. | Conserved hypothetical protein; Involved in DNA damage repair. | 0.542 |
SSB | SSO0931 | SSO2364 | SSO0931 | Single-stranded DNA binding protein (SSB); Binds to ssDNA, binding approximately 5 nucleotides per monomer. Binding my be slightly cooperative. Inhibits the endonuclease activity of XPF. | Conserved hypothetical protein; Conserved in archaea. | 0.516 |
SSB | SSO6503 | SSO2364 | SSO6503 | Single-stranded DNA binding protein (SSB); Binds to ssDNA, binding approximately 5 nucleotides per monomer. Binding my be slightly cooperative. Inhibits the endonuclease activity of XPF. | Conserved hypothetical protein; Belongs to the UPF0147 family. | 0.523 |
SSB | cdc6-2 | SSO2364 | SSO0771 | Single-stranded DNA binding protein (SSB); Binds to ssDNA, binding approximately 5 nucleotides per monomer. Binding my be slightly cooperative. Inhibits the endonuclease activity of XPF. | Cell division control 6/orc1 protein homolog (cdc6-2); Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds both single-stranded and double-stranded DNA, with a preference for molecules that contain a bubble, a fork, or a tail. Has a weak ATPase activity. Stimulates the binding of the MCM helicase to the origin DNA, but strongly inhibits ATPase and DNA helicase activities of MCM. Also regulates the DNA polymerase and the nuclease activities of PolB1. | 0.797 |
SSB | nrd | SSO2364 | SSO0929 | Single-stranded DNA binding protein (SSB); Binds to ssDNA, binding approximately 5 nucleotides per monomer. Binding my be slightly cooperative. Inhibits the endonuclease activity of XPF. | Ribonucleotide reductase (nrd); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.585 |
SSB | priL | SSO2364 | SSO0557 | Single-stranded DNA binding protein (SSB); Binds to ssDNA, binding approximately 5 nucleotides per monomer. Binding my be slightly cooperative. Inhibits the endonuclease activity of XPF. | Conserved hypothetical protein; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. Possesses a template- independent 3'-terminal nucleotidyl transferase activity. | 0.875 |
SSB | priS | SSO2364 | SSO1048 | Single-stranded DNA binding protein (SSB); Binds to ssDNA, binding approximately 5 nucleotides per monomer. Binding my be slightly cooperative. Inhibits the endonuclease activity of XPF. | DNA primase, putative; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May [...] | 0.859 |
SSO0872 | SSB | SSO0872 | SSO2364 | Conserved hypothetical protein; Involved in DNA damage repair. | Single-stranded DNA binding protein (SSB); Binds to ssDNA, binding approximately 5 nucleotides per monomer. Binding my be slightly cooperative. Inhibits the endonuclease activity of XPF. | 0.542 |
SSO0872 | SSO0931 | SSO0872 | SSO0931 | Conserved hypothetical protein; Involved in DNA damage repair. | Conserved hypothetical protein; Conserved in archaea. | 0.514 |
SSO0872 | cdc6-2 | SSO0872 | SSO0771 | Conserved hypothetical protein; Involved in DNA damage repair. | Cell division control 6/orc1 protein homolog (cdc6-2); Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds both single-stranded and double-stranded DNA, with a preference for molecules that contain a bubble, a fork, or a tail. Has a weak ATPase activity. Stimulates the binding of the MCM helicase to the origin DNA, but strongly inhibits ATPase and DNA helicase activities of MCM. Also regulates the DNA polymerase and the nuclease activities of PolB1. | 0.654 |
SSO0872 | priL | SSO0872 | SSO0557 | Conserved hypothetical protein; Involved in DNA damage repair. | Conserved hypothetical protein; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. Possesses a template- independent 3'-terminal nucleotidyl transferase activity. | 0.581 |
SSO0872 | priS | SSO0872 | SSO1048 | Conserved hypothetical protein; Involved in DNA damage repair. | DNA primase, putative; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May [...] | 0.631 |
SSO0931 | SSB | SSO0931 | SSO2364 | Conserved hypothetical protein; Conserved in archaea. | Single-stranded DNA binding protein (SSB); Binds to ssDNA, binding approximately 5 nucleotides per monomer. Binding my be slightly cooperative. Inhibits the endonuclease activity of XPF. | 0.516 |
SSO0931 | SSO0872 | SSO0931 | SSO0872 | Conserved hypothetical protein; Conserved in archaea. | Conserved hypothetical protein; Involved in DNA damage repair. | 0.514 |
SSO0931 | SSO2743 | SSO0931 | SSO2743 | Conserved hypothetical protein; Conserved in archaea. | Conserved hypothetical protein; Involved in DNA damage repair. | 0.404 |
SSO0931 | SSO6503 | SSO0931 | SSO6503 | Conserved hypothetical protein; Conserved in archaea. | Conserved hypothetical protein; Belongs to the UPF0147 family. | 0.419 |
SSO0931 | cdc6-2 | SSO0931 | SSO0771 | Conserved hypothetical protein; Conserved in archaea. | Cell division control 6/orc1 protein homolog (cdc6-2); Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds both single-stranded and double-stranded DNA, with a preference for molecules that contain a bubble, a fork, or a tail. Has a weak ATPase activity. Stimulates the binding of the MCM helicase to the origin DNA, but strongly inhibits ATPase and DNA helicase activities of MCM. Also regulates the DNA polymerase and the nuclease activities of PolB1. | 0.409 |
SSO0931 | endA | SSO0931 | SSO0439 | Conserved hypothetical protein; Conserved in archaea. | tRNA intron endonuclease, putative; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. | 0.422 |
SSO0931 | nrd | SSO0931 | SSO0929 | Conserved hypothetical protein; Conserved in archaea. | Ribonucleotide reductase (nrd); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.650 |
SSO0931 | priL | SSO0931 | SSO0557 | Conserved hypothetical protein; Conserved in archaea. | Conserved hypothetical protein; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. Possesses a template- independent 3'-terminal nucleotidyl transferase activity. | 0.434 |