STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuA-22-isopropylmalate synthase (leuA-2); Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway. Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily. (461 aa)    
Predicted Functional Partners:
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.985
ilvD
Dihydroxy-acid dehydratase (ilvD); Amino Acid Biosynthesis; Belongs to the IlvD/Edd family.
  
 
 0.979
acaB-2
Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-2); Lipid metabolism.
  
 
 0.929
acaB-3
Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-3); Lipid metabolism.
  
 
 0.929
acaB-4
Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-4); Lipid metabolism.
  
 
 0.929
acaB-7
Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-7); Lipid metabolism.
  
 
 0.929
acaB-9
Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-9); Lipid metabolism.
  
 
 0.929
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
  
 
 0.927
leuA-1
2-isopropylmalate synthase, putative (leuA-1); Amino Acid Biosynthesis, Pyruvate; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
  
0.925
acsA-5
Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-5); Lipid metabolism.
  
 
 0.920
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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