STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdlCBenzoylformate decarboxylase (mdlC); Amino Acid Biosynthesis, Aromatic amino acids; Belongs to the TPP enzyme family. (503 aa)    
Predicted Functional Partners:
ilvB-4
Acetolactate synthase large subunit homolog (ilvB-4); Amino Acid Biosynthesis, Pyruvate; Belongs to the TPP enzyme family.
  
  
  0.853
araD
Mandelate racemase /muconate lactonizing enzyme related protein (MR/MLE); Catalyzes the dehydration of D-arabinonate to 2-keto-3-deoxy- D-arabinonate. Participates in a pentose oxidation pathway that converts D-arabinonate to 2-oxoglutarate.
     
 0.809
ilvD
Dihydroxy-acid dehydratase (ilvD); Amino Acid Biosynthesis; Belongs to the IlvD/Edd family.
 
  
 0.802
adh-2
Alcohol dehydrogenase (Zn containing) (adh-2); Energy Metabolism.
  
  
 0.795
ilvB-1
Acetolactate synthase large subunit homolog (ilvB-1); Amino Acid Biosynthesis, Pyruvate.
  
  
 
0.674
ilvB-2
Acetolactate synthase large subunit homolog (ilvB-2); Amino Acid Biosynthesis, Pyruvate.
  
  
 
0.672
ilvB-6
Acetolactate synthase large subunit homolog (ilvB-6); Amino Acid Biosynthesis, Pyruvate.
  
  
 
0.664
ilvC-1
Ketol-acid reductoisomerase (ilvC-1); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.606
leuA-3
2-isopropylmalate synthase, putative (leuA-3); Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). Carries out the first step of the leucine biosynthesis pathway.
 
 
 0.569
ilvC-2
Ketol-acid reductoisomerase (ilvC-2); Amino Acid Biosynthesis, Pyruvate; Belongs to the ketol-acid reductoisomerase family.
  
  
 0.554
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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