STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurrence
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[Homology]
Score
gdS-2Geranylgeranyl pyrophosphate synthetase, putative (gdS-2); Catalyzes consecutive E-type condensation of two isopentenyl pyrophosphate (IPP) molecules with an allylic substrate such as geranylgeranyl diphosphate (GGPP), farnesyl diphosphate (FPP) or geranyl diphosphate (GPP) to yield the medium-chain product trans-C30- hexaprenyl pyrophosphate (HexPP). GGPP is the physiological substrate. (281 aa)    
Predicted Functional Partners:
uppS
Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
  
 
 0.989
crtB
Phytoene synthetase (crtB); Cofactor Biosynthesis, Caretenoid Biosynthesis.
  
 0.946
gdS-1
Geranylgeranyl pyrophosphate synthetase (gdS-1); Catalyzes the condensation of isopentenyl pyrophosphate with the allylic pyrophosphates to yield geranylgeranyl diphosphate (GGPP) which is a precursor of the ether-linked lipids; Belongs to the FPP/GGPP synthase family.
  
  
0.943
ubiA-1
4-hydroxybenzoate octaprenyltransferase (ubiA-1); Cofactor Biosynthesis, Quinones.
  
 
 0.859
mtaP
5'-methylthioadenosine phosphorylase (mtaP); Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
       0.820
SSO2344
Hypothetical protein; Similarity with fungal farnesyl-pyrophosphate synthetase.
       0.820
rpl15AB
LSU ribosomal protein L15AB (rpl15AB); Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
 
    0.671
gpT-1
Purine phosphoribosyltransferase (gpT-1); Purines.
 
    0.634
ndk
Nucleoside diphosphate kinase (NDP kinase) (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
  
 
 0.626
MvaD
Diphosphomevalonate decarboxylase, putative; Catalyzes the decarboxylation of mevalonate 5-diphosphate (MVAPP) to isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. Belongs to the diphosphomevalonate decarboxylase family.
  
 
 0.604
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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