node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SSO0432 | argS | SSO0432 | SSO0857 | HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Arginyl-tRNA synthetase (argS); Translation, Aminoacyl tRNA synthetases; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.458 |
SSO0432 | guaA | SSO0432 | SSO2451 | HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase, glutamine amidotransferase domain (guaA); Catalyzes the synthesis of GMP from XMP. | 0.947 |
SSO0432 | guaA-2 | SSO0432 | SSO3232 | HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase, PP-ATPase domain (guaA); Catalyzes the synthesis of GMP from XMP. | 0.957 |
SSO0432 | map | SSO0432 | SSO0098 | HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Methionine aminopeptidase 2; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily. | 0.410 |
SSO0432 | purA | SSO0432 | SSO0242 | HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Adenylosuccinate synthase (IMP--aspartate ligase) (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.672 |
SSO0432 | purB | SSO0432 | SSO0240 | HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Adenylosuccinate lyase (adenylosuccinase)(ASL) (purB); Purines; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.482 |
argS | SSO0432 | SSO0857 | SSO0432 | Arginyl-tRNA synthetase (argS); Translation, Aminoacyl tRNA synthetases; Belongs to the class-I aminoacyl-tRNA synthetase family. | HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.458 |
argS | guaA | SSO0857 | SSO2451 | Arginyl-tRNA synthetase (argS); Translation, Aminoacyl tRNA synthetases; Belongs to the class-I aminoacyl-tRNA synthetase family. | GMP synthase, glutamine amidotransferase domain (guaA); Catalyzes the synthesis of GMP from XMP. | 0.772 |
argS | guaA-2 | SSO0857 | SSO3232 | Arginyl-tRNA synthetase (argS); Translation, Aminoacyl tRNA synthetases; Belongs to the class-I aminoacyl-tRNA synthetase family. | GMP synthase, PP-ATPase domain (guaA); Catalyzes the synthesis of GMP from XMP. | 0.904 |
argS | map | SSO0857 | SSO0098 | Arginyl-tRNA synthetase (argS); Translation, Aminoacyl tRNA synthetases; Belongs to the class-I aminoacyl-tRNA synthetase family. | Methionine aminopeptidase 2; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily. | 0.480 |
argS | purA | SSO0857 | SSO0242 | Arginyl-tRNA synthetase (argS); Translation, Aminoacyl tRNA synthetases; Belongs to the class-I aminoacyl-tRNA synthetase family. | Adenylosuccinate synthase (IMP--aspartate ligase) (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.440 |
argS | purB | SSO0857 | SSO0240 | Arginyl-tRNA synthetase (argS); Translation, Aminoacyl tRNA synthetases; Belongs to the class-I aminoacyl-tRNA synthetase family. | Adenylosuccinate lyase (adenylosuccinase)(ASL) (purB); Purines; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.655 |
argS | pyrH | SSO0857 | SSO0976 | Arginyl-tRNA synthetase (argS); Translation, Aminoacyl tRNA synthetases; Belongs to the class-I aminoacyl-tRNA synthetase family. | Uridylate kinase (pyrH); Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor. Is also able to phosphorylate dUMP, although much less efficiently. | 0.474 |
argS | rpl11AB | SSO0857 | SSO0346 | Arginyl-tRNA synthetase (argS); Translation, Aminoacyl tRNA synthetases; Belongs to the class-I aminoacyl-tRNA synthetase family. | LSU ribosomal protein L11AB (rpl11AB); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. | 0.796 |
guaA | SSO0432 | SSO2451 | SSO0432 | GMP synthase, glutamine amidotransferase domain (guaA); Catalyzes the synthesis of GMP from XMP. | HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.947 |
guaA | argS | SSO2451 | SSO0857 | GMP synthase, glutamine amidotransferase domain (guaA); Catalyzes the synthesis of GMP from XMP. | Arginyl-tRNA synthetase (argS); Translation, Aminoacyl tRNA synthetases; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.772 |
guaA | guaA-2 | SSO2451 | SSO3232 | GMP synthase, glutamine amidotransferase domain (guaA); Catalyzes the synthesis of GMP from XMP. | GMP synthase, PP-ATPase domain (guaA); Catalyzes the synthesis of GMP from XMP. | 0.998 |
guaA | map | SSO2451 | SSO0098 | GMP synthase, glutamine amidotransferase domain (guaA); Catalyzes the synthesis of GMP from XMP. | Methionine aminopeptidase 2; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily. | 0.805 |
guaA | purA | SSO2451 | SSO0242 | GMP synthase, glutamine amidotransferase domain (guaA); Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate synthase (IMP--aspartate ligase) (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.821 |
guaA | purB | SSO2451 | SSO0240 | GMP synthase, glutamine amidotransferase domain (guaA); Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate lyase (adenylosuccinase)(ASL) (purB); Purines; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.775 |