node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ST0165 | argH | STK_01650 | STK_15020 | Putative aminotransferase. | Argininosuccinate lyase; Protein synonym:arginosuccinase. | 0.493 |
ST0165 | hisA | STK_01650 | STK_14600 | Putative aminotransferase. | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino]imidazole-4-carboxamide isomerase. | 0.911 |
ST0165 | hisB | STK_01650 | STK_14610 | Putative aminotransferase. | Imidazoleglycerol-phosphate dehydratase. | 0.921 |
ST0165 | hisD | STK_01650 | STK_14640 | Putative aminotransferase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.922 |
ST0165 | hisE | STK_01650 | STK_14650 | Putative aminotransferase. | phosphoribosyl-ATP pyrophosphatase; N-term changed (-42). | 0.894 |
ST0165 | hisF | STK_01650 | STK_14620 | Putative aminotransferase. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.916 |
ST0165 | hisG | STK_01650 | STK_14590 | Putative aminotransferase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.898 |
ST0165 | hisH | STK_01650 | STK_14660 | Putative aminotransferase. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.917 |
ST0165 | hisI | STK_01650 | STK_14670 | Putative aminotransferase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.915 |
argH | ST0165 | STK_15020 | STK_01650 | Argininosuccinate lyase; Protein synonym:arginosuccinase. | Putative aminotransferase. | 0.493 |
argH | hisB | STK_15020 | STK_14610 | Argininosuccinate lyase; Protein synonym:arginosuccinase. | Imidazoleglycerol-phosphate dehydratase. | 0.424 |
argH | hisC | STK_15020 | STK_14580 | Argininosuccinate lyase; Protein synonym:arginosuccinase. | Histidinol-phosphate aminotransferase; N-term changed (+213). | 0.493 |
argH | hisD | STK_15020 | STK_14640 | Argininosuccinate lyase; Protein synonym:arginosuccinase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.784 |
argH | hisF | STK_15020 | STK_14620 | Argininosuccinate lyase; Protein synonym:arginosuccinase. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.476 |
argH | hisG | STK_15020 | STK_14590 | Argininosuccinate lyase; Protein synonym:arginosuccinase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.616 |
argH | hisI | STK_15020 | STK_14670 | Argininosuccinate lyase; Protein synonym:arginosuccinase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.700 |
hisA | ST0165 | STK_14600 | STK_01650 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino]imidazole-4-carboxamide isomerase. | Putative aminotransferase. | 0.911 |
hisA | hisB | STK_14600 | STK_14610 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino]imidazole-4-carboxamide isomerase. | Imidazoleglycerol-phosphate dehydratase. | 0.999 |
hisA | hisC | STK_14600 | STK_14580 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino]imidazole-4-carboxamide isomerase. | Histidinol-phosphate aminotransferase; N-term changed (+213). | 0.987 |
hisA | hisD | STK_14600 | STK_14640 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino]imidazole-4-carboxamide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |