STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mcr/scrmalonyl-CoA/succinyl-CoA reductase; Catalyzes the reduction of malonyl-CoA to malonate semialdehyde, a key step in the 3-hydroxypropanoate and the 3- hydroxypropanoate/4-hydroxybutyrate cycles. Can also use succinyl-CoA and succinate semialdehyde as substrates but at a lower rate than malonyl-CoA. (359 aa)    
Predicted Functional Partners:
accB
acetyl-CoA/propionyl-CoA carboxylase beta subunit; N-term changed (-6); N-terminus of this ORF was identified by Edman sequencing; protein synonym:biotin carboxyl carrier protein.
    
 0.972
ST0064
Succinate-semialdehyde dehydrogenase.
  
 
 0.955
lysC
Protein synonym:aspartokinase; Belongs to the aspartokinase family.
 
  
 0.940
sucC
succinyl-CoA synthetase beta subunit; N-term changed (+195); N-terminus of this ORF was identified by Edman sequencing; protein synonym:succinate---CoA ligase.
  
 
 0.922
accC
acetyl-CoA/propionyl-CoA carboxylase alpha subunit; Protein synonym:biotin carboxylase.
    
 0.920
sucD
succinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.917
ST1507
Malonate-semialdehyde reductase; Protein synonym:3-hydroxypropionate dehydrogenase.
    
 0.916
ssr
Succinate-semialdehyde reductase.
    
 0.916
pccB
acetyl-CoA/propionyl-CoA carboxylase gamma subunit; N-term changed (-6); protein synonym:carboxyltransferase.
    
 0.915
ST0552
methylmalonyl-CoA mutase large subunit.
    
 0.911
Your Current Organism:
Sulfurisphaera tokodaii
NCBI taxonomy Id: 273063
Other names: S. tokodaii str. 7, Sulfolobus sp. (strain 7), Sulfolobus sp. 7, Sulfolobus tokodaii str. 7, Sulfurisphaera tokodaii str. 7, Sulfurisphaera tokodaii strain 7
Server load: medium (66%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.