STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HypFHydrogenase maturation factor; Best Blastp hit = gi|7449699|pir||B70359 transcription regulator HypF - Aquifex aeolicus gi|2983269|gb|AAC06863.1| (AE000701) transcriptional regulatory protein HypF [Aquifex aeolicus], score 587, E-value 1.00E-166. (751 aa)    
Predicted Functional Partners:
HypE
Hydrogenase maturation factor; Best Blastp hit = gi|12232077|gb|AAG49379.1|AF325724_2 (AF325724) HypE-like protein [Nostoc punctiforme], score 333, E-value 2.00E-90.
 
 
 0.999
HypB
Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; Best Blastp hit = gi|3024003|sp|Q43949|HYPB_AZOCH HYDROGENASE EXPRESSION/FORMATION PROTEIN HYPB gi|484409|pir||JN0647 hydrogenase expression/formation protein HupB - Azotobacter chroococcum gi|289235|gb|AAA22133.1| (L00674) hydrogenase accessory protein HupB [Azotobacter chroococcum], score 187, E-value 8.00E-47.
 
   
 0.988
HypC
Hydrogenase maturation factor; Best Blastp hit = gi|7515025|pir||F75031 hydrogenase expression/formation protein (hypc) PAB7315 - Pyrococcus abyssi (strain Orsay) gi|5458660|emb|CAB50147.1| (AJ248287) hydrogenase expression/formation protein (hypC) [Pyrococcus abyssi], score 68.2, E-value 1.00E-11.
 
 
 0.987
HybF
Zn finger protein HypA/HybF (possibly regulating hydrogenase expression); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
   
 0.986
HypD
Hydrogenase maturation factor; Best Blastp hit = gi|12232076|gb|AAG49378.1|AF325724_1 (AF325724) HypD-like protein [Nostoc punctiforme], score 323, E-value 3.00E-87.
 
  
 0.985
HypE2
Hydrogenase maturation factor; Best Blastp hit = gi|7447557|pir||F75178 hydrogenase expression/formation related protein PAB0403 - Pyrococcus abyssi (strain Orsay) gi|5458019|emb|CAB49509.1| (AJ248284) hydrogenase expression/formation related protein [Pyrococcus abyssi], score 249, E-value 4.00E-65.
 
 
 0.903
NuoI
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I); Best Blastp hit = gi|3005972|emb|CAA76122.1| (Y16191) echF [Methanosarcina barkeri], score 98.6, E-value 3.00E-20.
  
  
 0.860
NuoD
NADH:ubiquinone oxidoreductase 49 kD subunit 7; Best Blastp hit = gi|3005971|emb|CAA76121.1| (Y16191) echE [Methanosarcina barkeri], score 424, E-value 1.00E-118.
     
 0.859
NuoH
NADH:ubiquinone oxidoreductase subunit 1 (chain H); Best Blastp hit = gi|3005968|emb|CAA76118.1| (Y16191) echB [Methanosarcina barkeri], score 247, E-value 2.00E-64.
     
 0.848
NuoL
NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit; Best Blastp hit = gi|3005967|emb|CAA76117.1| (Y16191) echA [Methanosarcina barkeri], score 345, E-value 1.00E-93.
       0.841
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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