STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TdkThymidine kinase; Best Blastp hit = gi|729902|sp|Q03221|KITH_BACSU THYMIDINE KINASE gi|1075925|pir||S55432 thymidine kinase (EC 2.7.1.21) tdk - Bacillus subtilis gi|405819|gb|AAA02902.1| (M97678) thymidine kinase [Bacillus subtilis] gi|853771|emb|CAA89879.1| (Z49782) thymidine kinase [Bacillus subtilis] gi|2636231|emb|CAB15723.1| (Z99122) thymidine kinase [Bacillus subtilis] gi|2636243|emb|CAB15734.1| (Z99123) thymidine kinase [Bacillus subtilis], score 231, E-value 4.00E-60. (193 aa)    
Predicted Functional Partners:
Dut
dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
   
 
 0.962
PrfA
Protein chain release factor A; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
  
  
 0.953
ComEB
Deoxycytidylate deaminase; Best Blastp hit = gi|11499353|ref|NP_070592.1| 'dCMP deaminase, putative [Archaeoglobus fulgidus]' gi|7448896|pir||C69470 dCMP deaminase homolog - Archaeoglobus fulgidus gi|2648787|gb|AAB89487.1| '(AE000981) dCMP deaminase, putative [Archaeoglobus fulgidus]', score 200, E-value 9.00E-51.
  
 
 0.952
Tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.938
UshA
5-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Best Blastp hit = gi|7481086|pir||T35760 probable nucleotidase - Streptomyces coelicolor gi|5689908|emb|CAB52071.1| (AL109732) putative nucleotidase [Streptomyces coelicolor A3(2)], score 325, E-value 3.00E-87.
 
  
  0.933
DeoA
Thymidine phosphorylase; Best Blastp hit = gi|2501426|sp|P77836|PDP_BACST PYRIMIDINE-NUCLEOSIDE PHOSPHORYLASE (PYNP) gi|2126872|pir||JT0875 pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) - Bacillus stearothermophilus gi|2126873|pir||JC4992 pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) - Bacillus stearothermophilus gi|1620901|dbj|BAA13512.1| (D87961) Pyrimidine nucleoside phosphorylase [Bacillus stearothermophilus], score 496, E-value 1.00E-139.
    
 0.930
Cdd
Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.
    
 0.922
DeoD
Purine-nucleoside phosphorylase; Best Blastp hit = gi|6647707|sp|O34925|DEOD_BACSU PURINE NUCLEOSIDE PHOSPHORYLASE II (PNP II) (PU-NPASE II) gi|7450027|pir||D69614 purine nucleoside phosphorylase deoD - Bacillus subtilis gi|2415397|gb|AAB72065.1| (AF015775) purine nucleoside phosphorylase [Bacillus subtilis] gi|2529472|gb|AAB81164.1| (AF006665) YokY [Bacillus subtilis] gi|2634355|emb|CAB13854.1| (Z99114) purine nucleoside phosphorylase [Bacillus subtilis], score 310, E-value 1.00E-83.
  
 
 0.921
SurE
Survival protein, predicted acid phosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
  
  
  0.917
HemK
Predicted rRNA or tRNA methylase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
  
  
 0.860
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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