STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
UppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (210 aa)    
Predicted Functional Partners:
Udk
Uridine kinase; Best Blastp hit = gi|7462984|pir||B72341 uridine kinase-related protein - Thermotoga maritima (strain MSB8) gi|4981276|gb|AAD35832.1|AE001744_22 (AE001744) uridine kinase-related protein [Thermotoga maritima], score 541, E-value 1.00E-153.
  
 0.990
RpiB
Ribose 5-phosphate isomerase RpiB; Best Blastp hit = gi|10176391|dbj|BAB07486.1| (AP001519) ribose 5-phosphate epimerase (pentose phosphate) [Bacillus halodurans], score 167, E-value 1.00E-40; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
 
  
 0.985
GuaA
GMP synthase - PP-ATPase domain protein; Catalyzes the synthesis of GMP from XMP.
  
  
 0.971
PyrF
Orotidine-5-phosphate decarboxylase; Best Blastp hit = gi|7107278|gb|AAF36353.1|AF187997_1 (AF187997) orotidine-5'-monophosphate decarboxylase [Halobacterium salinarum] gi|10581143|gb|AAG19923.1| (AE005076) orotidine-5'-monophosphate (Ura3); PyrF [Halobacterium sp. NRC-1], score 148, E-value 8.00E-35; Belongs to the OMP decarboxylase family. Type 2 subfamily.
  
 
 0.966
PyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
  
 
 0.961
DeoA
Thymidine phosphorylase; Best Blastp hit = gi|2501426|sp|P77836|PDP_BACST PYRIMIDINE-NUCLEOSIDE PHOSPHORYLASE (PYNP) gi|2126872|pir||JT0875 pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) - Bacillus stearothermophilus gi|2126873|pir||JC4992 pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) - Bacillus stearothermophilus gi|1620901|dbj|BAA13512.1| (D87961) Pyrimidine nucleoside phosphorylase [Bacillus stearothermophilus], score 496, E-value 1.00E-139.
  
 
 0.954
PyrR
Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
     
 0.927
DeoD
Purine-nucleoside phosphorylase; Best Blastp hit = gi|6647707|sp|O34925|DEOD_BACSU PURINE NUCLEOSIDE PHOSPHORYLASE II (PNP II) (PU-NPASE II) gi|7450027|pir||D69614 purine nucleoside phosphorylase deoD - Bacillus subtilis gi|2415397|gb|AAB72065.1| (AF015775) purine nucleoside phosphorylase [Bacillus subtilis] gi|2529472|gb|AAB81164.1| (AF006665) YokY [Bacillus subtilis] gi|2634355|emb|CAB13854.1| (Z99114) purine nucleoside phosphorylase [Bacillus subtilis], score 310, E-value 1.00E-83.
    
 0.911
SurE
Survival protein, predicted acid phosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
 0.909
IndA
Uncharacterized enzyme involved in pigment biosynthesis; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family.
    
  0.905
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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