node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GuaA | GuaB | TTE0583 | TTE0582 | GMP synthase - PP-ATPase domain protein; Catalyzes the synthesis of GMP from XMP. | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
GuaA | PurC | TTE0583 | TTE0588 | GMP synthase - PP-ATPase domain protein; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; Best Blastp hit = gi|10173240|dbj|BAB04345.1| (AP001509) phosphoribosylaminoimidazole succinocarboxamide synthetase [Bacillus halodurans], score 266, E-value 2.00E-70; Belongs to the SAICAR synthetase family. | 0.799 |
GuaA | PurD | TTE0583 | TTE0593 | GMP synthase - PP-ATPase domain protein; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylamine-glycine ligase; Best Blastp hit = gi|10173248|dbj|BAB04353.1| (AP001509) phosphoribosylglycinamide synthetase [Bacillus halodurans], score 408, E-value 1.00E-113. | 0.953 |
GuaA | PurE | TTE0583 | TTE0585 | GMP synthase - PP-ATPase domain protein; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.858 |
GuaA | PurH | TTE0583 | TTE0592 | GMP synthase - PP-ATPase domain protein; Catalyzes the synthesis of GMP from XMP. | AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); Best Blastp hit = gi|10173247|dbj|BAB04352.1| (AP001509) phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [Bacillus halodurans], score 611, E-value 1.00E-174. | 0.930 |
GuaA | PurL2 | TTE0583 | TTE0811 | GMP synthase - PP-ATPase domain protein; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and [...] | 0.948 |
GuaA | PurM | TTE0583 | TTE0590 | GMP synthase - PP-ATPase domain protein; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylaminoimidazol (AIR) synthetase; Best Blastp hit = gi|11272453|pir||E81104 phosphoribosylformylglycinamidine cyclo-ligase NMB1252 [imported] - Neisseria meningitidis (group B strain MD58) gi|7226492|gb|AAF41632.1| (AE002473) phosphoribosylformylglycinamidine cyclo-ligase [Neisseria meningitidis MC58], score 375, E-value 1.00E-103. | 0.817 |
GuaA | PurN | TTE0583 | TTE0591 | GMP synthase - PP-ATPase domain protein; Catalyzes the synthesis of GMP from XMP. | Folate-dependent phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.797 |
GuaA | TTE0584 | TTE0583 | TTE0584 | GMP synthase - PP-ATPase domain protein; Catalyzes the synthesis of GMP from XMP. | Permeases; Best Blastp hit = gi|2833499|sp|Q57772|Y326_METJA HYPOTHETICAL PROTEIN MJ0326 gi|2128002|pir||F64340 hypothetical protein homolog MJ0326 - Methanococcus jannaschii gi|1591045|gb|AAB98314.1| (U67487) conserved hypothetical protein [Methanococcus jannaschii], score 406, E-value 1.00E-112. | 0.772 |
GuaA | UraA | TTE0583 | TTE2407 | GMP synthase - PP-ATPase domain protein; Catalyzes the synthesis of GMP from XMP. | Xanthine/uracil permeases; Best Blastp hit = gi|6688613|emb|CAB65186.1| (AJ012720) uracil permease [Lactobacillus plantarum], score 340, E-value 2.00E-92. | 0.757 |
GuaB | GuaA | TTE0582 | TTE0583 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase - PP-ATPase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.999 |
GuaB | PurC | TTE0582 | TTE0588 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; Best Blastp hit = gi|10173240|dbj|BAB04345.1| (AP001509) phosphoribosylaminoimidazole succinocarboxamide synthetase [Bacillus halodurans], score 266, E-value 2.00E-70; Belongs to the SAICAR synthetase family. | 0.808 |
GuaB | PurD | TTE0582 | TTE0593 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylamine-glycine ligase; Best Blastp hit = gi|10173248|dbj|BAB04353.1| (AP001509) phosphoribosylglycinamide synthetase [Bacillus halodurans], score 408, E-value 1.00E-113. | 0.864 |
GuaB | PurE | TTE0582 | TTE0585 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.889 |
GuaB | PurH | TTE0582 | TTE0592 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); Best Blastp hit = gi|10173247|dbj|BAB04352.1| (AP001509) phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [Bacillus halodurans], score 611, E-value 1.00E-174. | 0.992 |
GuaB | PurL2 | TTE0582 | TTE0811 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and [...] | 0.839 |
GuaB | PurM | TTE0582 | TTE0590 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylaminoimidazol (AIR) synthetase; Best Blastp hit = gi|11272453|pir||E81104 phosphoribosylformylglycinamidine cyclo-ligase NMB1252 [imported] - Neisseria meningitidis (group B strain MD58) gi|7226492|gb|AAF41632.1| (AE002473) phosphoribosylformylglycinamidine cyclo-ligase [Neisseria meningitidis MC58], score 375, E-value 1.00E-103. | 0.925 |
GuaB | PurN | TTE0582 | TTE0591 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Folate-dependent phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.818 |
GuaB | TTE0584 | TTE0582 | TTE0584 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Permeases; Best Blastp hit = gi|2833499|sp|Q57772|Y326_METJA HYPOTHETICAL PROTEIN MJ0326 gi|2128002|pir||F64340 hypothetical protein homolog MJ0326 - Methanococcus jannaschii gi|1591045|gb|AAB98314.1| (U67487) conserved hypothetical protein [Methanococcus jannaschii], score 406, E-value 1.00E-112. | 0.747 |
GuaB | UraA | TTE0582 | TTE2407 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Xanthine/uracil permeases; Best Blastp hit = gi|6688613|emb|CAB65186.1| (AJ012720) uracil permease [Lactobacillus plantarum], score 340, E-value 2.00E-92. | 0.705 |