STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TTE0584Permeases; Best Blastp hit = gi|2833499|sp|Q57772|Y326_METJA HYPOTHETICAL PROTEIN MJ0326 gi|2128002|pir||F64340 hypothetical protein homolog MJ0326 - Methanococcus jannaschii gi|1591045|gb|AAB98314.1| (U67487) conserved hypothetical protein [Methanococcus jannaschii], score 406, E-value 1.00E-112. (444 aa)    
Predicted Functional Partners:
PurE
Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
    0.866
GuaA
GMP synthase - PP-ATPase domain protein; Catalyzes the synthesis of GMP from XMP.
     
 0.772
UraA
Xanthine/uracil permeases; Best Blastp hit = gi|6688613|emb|CAB65186.1| (AJ012720) uracil permease [Lactobacillus plantarum], score 340, E-value 2.00E-92.
 
  
 0.755
GuaB
IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.747
PurD
Phosphoribosylamine-glycine ligase; Best Blastp hit = gi|10173248|dbj|BAB04353.1| (AP001509) phosphoribosylglycinamide synthetase [Bacillus halodurans], score 408, E-value 1.00E-113.
  
  
 0.717
PurM
Phosphoribosylaminoimidazol (AIR) synthetase; Best Blastp hit = gi|11272453|pir||E81104 phosphoribosylformylglycinamidine cyclo-ligase NMB1252 [imported] - Neisseria meningitidis (group B strain MD58) gi|7226492|gb|AAF41632.1| (AE002473) phosphoribosylformylglycinamidine cyclo-ligase [Neisseria meningitidis MC58], score 375, E-value 1.00E-103.
  
  
 0.707
PurH
AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); Best Blastp hit = gi|10173247|dbj|BAB04352.1| (AP001509) phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [Bacillus halodurans], score 611, E-value 1.00E-174.
  
  
 0.699
PurN
Folate-dependent phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
  
  
 0.692
PurC
Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; Best Blastp hit = gi|10173240|dbj|BAB04345.1| (AP001509) phosphoribosylaminoimidazole succinocarboxamide synthetase [Bacillus halodurans], score 266, E-value 2.00E-70; Belongs to the SAICAR synthetase family.
  
  
 0.665
PurL2
Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and [...]
  
  
 0.603
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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