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FolD protein (Caldanaerobacter subterraneus) - STRING interaction network
"FolD" - Bifunctional protein FolD in Caldanaerobacter subterraneus
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second shell of interactors
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proteins of unknown 3D structure
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
FolDBifunctional protein FolD; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (280 aa)    
Predicted Functional Partners:
MIS1
Formate--tetrahydrofolate ligase; Best Blastp hit = gi|120563|sp|P21164|FTHS_MOOTH FORMATE--TETRAHYDROFOLATE LIGASE (FORMYLTETRAHYDROFOLATE SYNTHETASE) (FHS) (FTHFS) gi|98640|pir||A35942 formate--tetrahydrofolate ligase (EC 6.3.4.3) - Clostridium thermaceticum gi|144816|gb|AAA23240.1| (J02911) formyltetrahydrofolate synthetase (FTHFS) (ttg start codon) (EC 6.3.4.3) [Moorella thermoacetica], score 744, E-value 0 (555 aa)
 
 
  0.996
GlyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (413 aa)
 
 
  0.993
TTE0456
Methenyl tetrahydrofolate cyclohydrolase; Best Blastp hit = gi|13540921|ref|NP_110609.1| Formiminotransferase cyclodeaminase [Thermoplasma volcanium], score 107, E-value 1.00E-22 (238 aa)
     
  0.991
GcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (374 aa)
   
 
  0.987
PurH
Bifunctional purine biosynthesis protein PurH; Best Blastp hit = gi|10173247|dbj|BAB04352.1| (AP001509) phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [Bacillus halodurans], score 611, E-value 1.00E-174 (508 aa)
 
  0.982
NusB
Transcription antitermination protein NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons (140 aa)
 
   
  0.975
Fmt
Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus (309 aa)
 
 
  0.970
PurN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate (207 aa)
 
  0.960
GuaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP (512 aa)
   
   
  0.948
IspA
Best Blastp hit = gi|7447349|pir||S74538 geranylgeranyl pyrophosphate synthase - Synechocystis sp. (strain PCC 6803) gi|1651762|dbj|BAA16690.1| (D90899) geranylgeranyl pyrophosphate synthase [Synechocystis sp.], score 273, E-value 2.00E-72; Belongs to the FPP/GGPP synthase family (294 aa)
     
 
  0.915
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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