STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RsbW3Anti-sigma regulatory factor (Ser/Thr protein kinase); Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. (143 aa)    
Predicted Functional Partners:
SpoIIAA
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor); Best Blastp hit = gi|10174153|dbj|BAB05255.1| (AP001512) anti-sigma F factor antagonist (stage II sporulation protein AA) [Bacillus halodurans], score 100, E-value 5.00E-21; Belongs to the anti-sigma-factor antagonist family.
 
 
 0.997
FliA2
DNA-directed RNA polymerase specialized sigma subunit; Best Blastp hit = gi|2529267|gb|AAB81186.1| (L47358) sigma factor [Paenibacillus polymyxa], score 232, E-value 3.00E-60; Belongs to the sigma-70 factor family.
 
 
 0.992
TTE1048
STAS domain protein; Best Blastp hit = gi|10173137|dbj|BAB04243.1| (AP001508) negative regulator of sigma-B activity (antagonist of RsbT) [Bacillus halodurans], score 82.8, E-value 2.00E-15.
 
 
 0.922
TTE1047
STAS domain protein; Best Blastp hit = gi|10957445|ref|NP_051565.1| sigma-B regulator RsbR [Deinococcus radiodurans] gi|7473909|pir||F75620 sigma-B regulator RsbR - Deinococcus radiodurans (strain R1) gi|6460874|gb|AAF12578.1|AE001826_47 (AE001826) sigma-B regulator RsbR [Deinococcus radiodurans], score 115, E-value 6.00E-25.
 
 
 0.921
TTE1319
Spore formation protein spoVAC; Best Blastp hit = gi|730784|sp|P40868|SP53_BACSU STAGE V SPORULATION PROTEIN AC gi|7475849|pir||F69714 spore formation protein spoVAC - Bacillus subtilis gi|1304003|dbj|BAA12658.1| (D84432) SpoVAC [Bacillus subtilis] gi|2634777|emb|CAB14274.1| (Z99116) mutants lead to the production of immature spores (stage V sporulation) [Bacillus subtilis], score 137, E-value 5.00E-32.
 
   
 0.921
TTE1320
Spore formation protein spoVAD; Best Blastp hit = gi|730785|sp|P40869|SP54_BACSU STAGE V SPORULATION PROTEIN AD gi|7475850|pir||G69714 spore formation protein spoVAD - Bacillus subtilis gi|1304004|dbj|BAA12659.1| (D84432) SpoVAD [Bacillus subtilis] gi|2634776|emb|CAB14273.1| (Z99116) mutants lead to the production of immature spores (stage V sporulation) [Bacillus subtilis], score 301, E-value 6.00E-81.
 
  
 0.918
TTE1321
Sporulation protein; Best Blastp hit = gi|10174187|dbj|BAB05289.1| (AP001512) sporulation protein [Bacillus halodurans], score 90.1, E-value 9.00E-18.
 
     0.914
TTE0170
Transcription regulator of sigma-E/sigma-K-dependent gene spoIIID; Best Blastp hit = gi|134766|sp|P15281|SP3D_BACSU STAGE III SPORULATION PROTEIN D (14 KD TRANSCRIPTION FACTOR) gi|98493|pir||A33472 transcription regulator of sigma-E/sigma-K-dependent gene spoIIID - Bacillus subtilis gi|580763|emb|CAA33541.1| (X15520) transcription factor (AA 1-93) [Bacillus subtilis] gi|580931|emb|CAA36295.1| (X52076) spoIIID protein (AA 1-93) [Bacillus subtilis] gi|1684653|emb|CAB05384.1| (Z82987) SpoIIID [Bacillus subtilis] gi|2636167|emb|CAB15659.1| (Z99122) transcriptional regulator [Bacillus subti [...]
  
   
 0.888
CheY7
CheY-like receiver domains; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
 
  
 0.881
TTE2552
pro-sigma-E processing factor spoIIR; Best Blastp hit = gi|730770|sp|P39151|SP2R_BACSU STAGE II SPORULATION PROTEIN R gi|2127223|pir||I40474 pro-sigma-E processing factor spoIIR - Bacillus subtilis gi|556879|emb|CAA86103.1| (Z38002) Unknown [Bacillus subtilis] gi|2636222|emb|CAB15714.1| '(Z99122) alternate gene name: ipc-27d, csfX [Bacillus subtilis]' gi|1095417|prf||2108403B spoIIR gene [Bacillus subtilis], score 120, E-value 1.00E-26.
  
   
 0.863
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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