STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BcpPeroxiredoxin; Best Blastp hit = gi|10173563|dbj|BAB04667.1| (AP001510) bacterioferritin comigratory protein [Bacillus halodurans], score 175, E-value 2.00E-43. (157 aa)    
Predicted Functional Partners:
RpsD
Ribosomal protein S4 and related proteins; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
 
      0.701
GrxC
Glutaredoxin and related proteins; Best Blastp hit = gi|7451278|pir||F72303 glutaredoxin - Thermotoga maritima (strain MSB8) gi|4981572|gb|AAD36108.1|AE001764_11 (AE001764) glutaredoxin [Thermotoga maritima], score 90.9, E-value 1.00E-17.
  
 
 0.643
PabA
Best Blastp hit = gi|7436747|pir||E70349 anthranilate synthase component II - Aquifex aeolicus gi|2983181|gb|AAC06781.1| (AE000695) anthranilate synthase component II [Aquifex aeolicus], score 257, E-value 7.00E-68.
 
    0.637
TrpC
Best Blastp hit = gi|11268627|pir||E81395 indole-3-glycerol phosphate synthase (EC 4.1.1.48) Cj0498 [imported] - Campylobacter jejuni (strain NCTC 11168) gi|6967969|emb|CAB75136.1| (AL139075) indole-3-glycerol phosphate synthase [Campylobacter jejuni], score 177, E-value 1.00E-43; Belongs to the TrpC family.
  
    0.632
TrpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
  
    0.603
TrpE
Anthranilate/para-aminobenzoate synthases component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorisma [...]
       0.591
TrpB
Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
       0.590
TrpF
Phosphoribosylanthranilate isomerase; Best Blastp hit = gi|8569669|pdb|1DL3|A 'Chain A, Crystal Structure Of Mutually Generated Monomers Of Dimeric Phosphoribosylantranilate Isomerase From Thermotoga Maritim' gi|8569670|pdb|1DL3|B 'Chain B, Crystal Structure Of Mutually Generated Monomers Of Dimeric Phosphoribosylantranilate Isomerase From Thermotoga Maritim', score 144, E-value 9.00E-34; Belongs to the TrpF family.
       0.587
TrpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
       0.585
AroA3
3-Deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Best Blastp hit = gi|7436656|pir||B75161 phospho-2-dehydro-3-deoxyheptonate aldolase PAB0297 - Pyrococcus abyssi (strain Orsay) gi|5457879|emb|CAB49369.1| (AJ248284) PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE [Pyrococcus abyssi], score 311, E-value 4.00E-84.
       0.579
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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