STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PheTBest Blastp hit = gi|3123292|sp|P17922|SYFB_BACSU PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN (PHENYLALANINE--TRNA LIGASE BETA CHAIN) (PHERS) gi|7428487|pir||YFBSB phenylalanine--tRNA ligase (EC 6.1.1.20) beta chain - Bacillus subtilis gi|1770031|emb|CAA99564.1| (Z75208) phenylalanyl-tRNA synthetase beta subunit [Bacillus subtilis] gi|2635328|emb|CAB14823.1| (Z99118) phenylalanyl-tRNA synthetase (beta subunit) [Bacillus subtilis], score 591, E-value 1.00E-167. (794 aa)    
Predicted Functional Partners:
PheS
Best Blastp hit = gi|2507429|sp|P17921|SYFA_BACSU PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN (PHENYLALANINE--TRNA LIGASE ALPHA CHAIN) (PHERS) gi|7428485|pir||YFBSA phenylalanine--tRNA ligase (EC 6.1.1.20) alpha chain - Bacillus subtilis gi|1770030|emb|CAA99603.1| (Z75208) phenylalany-tRNA synthetase beta subunit [Bacillus subtilis] gi|2635329|emb|CAB14824.1| (Z99118) phenylalanyl-tRNA synthetase (alpha subunit) [Bacillus subtilis], score 421, E-value 1.00E-117; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
 
 0.999
IleS
Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
  
 
 0.990
LeuS
Leucyl-tRNA synthetase; Best Blastp hit = gi|6919980|sp|Q9WY15|SYL_THEMA LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS) gi|7437543|pir||F72408 leucine--tRNA ligase (EC 6.1.1.4) - Thermotoga maritima (strain MSB8) gi|4980663|gb|AAD35261.1|AE001702_1 (AE001702) leucyl-tRNA synthetase [Thermotoga maritima], score 840, E-value 0; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
  
 0.985
RpsB
Ribosomal protein S2; Best Blastp hit = gi|10175047|dbj|BAB06146.1| (AP001515) 30S ribosomal protein S2 [Bacillus halodurans], score 367, E-value 1.00E-100; Belongs to the universal ribosomal protein uS2 family.
 
 
 0.956
GuaB
IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.948
MetG
Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
  
 0.947
GuaA
GMP synthase - PP-ATPase domain protein; Catalyzes the synthesis of GMP from XMP.
  
  
 0.947
RpoB
DNA-directed RNA polymerase beta subunit/140 kD subunit (split gene in Mjan, Mthe, Aful); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
 
  
 0.941
RpsC
Ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family.
  
 
 0.937
RplO
Ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
  
  
 0.931
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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