STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HyfB2Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit; Best Blastp hit = gi|13362814|dbj|BAB36767.1| (AP002561) hydrogenase 4 membrane subunit [Escherichia coli O157:H7], score 505, E-value 1.00E-142. (673 aa)    
Predicted Functional Partners:
HycE
Ni,Fe-hydrogenase III large subunit; Best Blastp hit = gi|123919|sp|P16431|HYCE_ECOLI FORMATE HYDROGENLYASE SUBUNIT 5 PRECURSOR (FHL SUBUNIT 5) (HYDROGENASE-3 COMPONENT E) gi|78775|pir||S08623 hydrogenase (EC 1.18.99.1) 3 chain 5 precursor - Escherichia coli gi|41684|emb|CAA35550.1| (X17506) hycE [Escherichia coli] gi|882614|gb|AAA69231.1| (U29579) formate hydrogenlyase subunit 5 [Escherichia coli] gi|1789076|gb|AAC75763.1| (AE000356) large subunit of hydrogenase 3 (part of FHL complex) [Escherichia coli K12] gi|1093498|prf||2104213E hycE gene [Escherichia coli], score 755, E-value 0.
 
 0.999
HyfC
Formate hydrogenlyase subunit 4; Best Blastp hit = gi|13362815|dbj|BAB36768.1| (AP002561) hydrogenase 4 membrane subunit [Escherichia coli O157:H7], score 277, E-value 2.00E-73.
 
 
 0.993
TTE1698
Ni,Fe-hydrogenase III small subunit; Best Blastp hit = gi|2506958|sp|P16433|HYCG_ECOLI FORMATE HYDROGENLYASE SUBUNIT 7 (FHL SUBUNIT 7) (HYDROGENASE-3 COMPONENT G) gi|78777|pir||S08625 hydrogenase (EC 1.18.99.1) 3 chain 7 - Escherichia coli gi|882612|gb|AAA69229.1| (U29579) formate hydrogenlyase subunit 7 [Escherichia coli] gi|1789074|gb|AAC75761.1| (AE000356) hydrogenase activity [Escherichia coli K12], score 274, E-value 1.00E-72.
 
 
 0.987
NuoL2
NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit; Best Blastp hit = gi|2499290|sp|P77416|HYFD_ECOLI HYDROGENASE-4 COMPONENT D gi|7466377|pir||C65024 hypothetical protein b2484 - Escherichia coli (strain K-12) gi|1616953|gb|AAB88566.1| (M63654) Hyf D [Escherichia coli] gi|1788829|gb|AAC75537.1| (AE000335) hydrogenase 4 membrane subunit [Escherichia coli K12] gi|1805543|dbj|BAA16372.1| (D90877) NADH dehydrogenase (ubiquinone) (EC 1.6.5.3) chain 5 [Escherichia coli], score 457, E-value 1.00E-127.
 
 
0.980
TTE1704
Hydrogenase 4 membrane subunit; Best Blastp hit = gi|2498472|sp|P77524|HYFE_ECOLI HYDROGENASE-4 COMPONENT E gi|7466378|pir||D65024 hypothetical protein b2485 - Escherichia coli (strain K-12) gi|1788830|gb|AAC75538.1| (AE000335) hydrogenase 4 membrane subunit [Escherichia coli K12] gi|1805544|dbj|BAA16373.1| (D90877) similar to [SwissProt Accession Number Q10882] [Escherichia coli] gi|2668497|gb|AAB88567.1| (M63654) hyf E [Escherichia coli] gi|12516870|gb|AAG57595.1|AE005478_5 (AE005478) hydrogenase 4 membrane subunit [Escherichia coli O157:H7 EDL933] gi|13362817|dbj|BAB36770.1| (AP0025 [...]
 
  
 0.973
NuoI2
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I); Best Blastp hit = gi|12517168|gb|AAG57827.1|AE005500_6 (AE005500) probable iron-sulfur protein of hydrogenase 3 (part of FHL complex) [Escherichia coli O157:H7 EDL933] gi|13363047|dbj|BAB36999.1| (AP002562) formate hydrogenlyase subunit-7 component F [Escherichia coli O157:H7], score 168, E-value 6.00E-41.
 
 
 0.972
NuoH
NADH:ubiquinone oxidoreductase subunit 1 (chain H); Best Blastp hit = gi|3005968|emb|CAA76118.1| (Y16191) echB [Methanosarcina barkeri], score 247, E-value 2.00E-64.
 
 0.950
NuoB
NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases; Best Blastp hit = gi|3005969|emb|CAA76119.1| (Y16191) echC [Methanosarcina barkeri], score 184, E-value 7.00E-46; Belongs to the complex I 20 kDa subunit family.
 
 
 0.938
NuoD
NADH:ubiquinone oxidoreductase 49 kD subunit 7; Best Blastp hit = gi|3005971|emb|CAA76121.1| (Y16191) echE [Methanosarcina barkeri], score 424, E-value 1.00E-118.
 
 0.935
NuoL
NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit; Best Blastp hit = gi|3005967|emb|CAA76117.1| (Y16191) echA [Methanosarcina barkeri], score 345, E-value 1.00E-93.
 
 
0.930
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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