STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ThiMHydroxyethylthiazole kinase, sugar kinase family; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (267 aa)    
Predicted Functional Partners:
ThiE
Thiamine monophosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 0.999
ThiD
Best Blastp hit = gi|11280145|pir||E81311 phosphomethylpyrimidine kinase (EC 2.7.4.7) Cj1082c [imported] - Campylobacter jejuni (strain NCTC 11168) gi|6968516|emb|CAB73337.1| (AL139077) phosphomethylpyrimidine kinase [Campylobacter jejuni], score 243, E-value 2.00E-63.
  
 0.998
ThiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.767
Tar9
Methyl-accepting chemotaxis protein; Best Blastp hit = gi|730002|sp|P39214|MCPA_BACSU METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPA (H1) gi|1075866|pir||B54078 methyl-accepting chemotaxis transducer mcpA - Bacillus subtilis gi|459690|gb|AAA20556.1| (L29189) transmembrane receptor [Bacillus subtilis] gi|2635608|emb|CAB15102.1| (Z99119) methyl-accepting chemotaxis protein [Bacillus subtilis] gi|2635620|emb|CAB15113.1| (Z99120) methyl-accepting chemotaxis protein [Bacillus subtilis], score 236, E-value 7.00E-61.
       0.732
CodB
Purine-cytosine permease and related proteins; Best Blastp hit = gi|11354034|pir||G82032 probable permease NMA0365 [imported] - Neisseria meningitidis (group A strain Z2491) gi|7379117|emb|CAB83666.1| (AL162752) putative permease [Neisseria meningitidis Z2491], score 177, E-value 3.00E-43.
 
    0.687
TTE1731
Conserved hypothetical protein; Best Blastp hit = gi|13701094|dbj|BAB42389.1| (AP003133) conserved hypothetical protein [Staphylococcus aureus] gi|13875607|dbj|BAB45849.1| (AP003361) conserved hypothetical protein [Staphylococcus aureus], score 118, E-value 5.00E-26.
 
     0.668
ThiH
Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes; Best Blastp hit = gi|7462818|pir||B72274 hypothetical protein TM1267 - Thermotoga maritima (strain MSB8) gi|4981824|gb|AAD36342.1|AE001782_3 '(AE001782) thiH protein, putative [Thermotoga maritima]', score 498, E-value 1.00E-140.
  
  
 0.613
GlmS
Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
      
 0.579
FabG5
Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Best Blastp hit = gi|1502421|gb|AAC44307.1| (U59433) 3-ketoacyl-acyl carrier protein reductase [Bacillus subtilis], score 148, E-value 8.00E-35.
       0.576
MetK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
      
 0.543
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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