node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FolD | GcvT | TTE1293 | TTE0296 | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system T protein (aminomethyltransferase); The glycine cleavage system catalyzes the degradation of glycine. | 0.960 |
FolD | GlyA | TTE1293 | TTE2130 | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.989 |
FolD | Icd | TTE1293 | TTE0387 | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Isocitrate dehydrogenases; Best Blastp hit = gi|7431248|pir||H72288 isocitrate dehydrogenase - Thermotoga maritima (strain MSB8) gi|4981696|gb|AAD36224.1|AE001772_3 (AE001772) isocitrate dehydrogenase [Thermotoga maritima], score 536, E-value 1.00E-151; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.898 |
FolD | MIS1 | TTE1293 | TTE2391 | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Formyltetrahydrofolate synthetase; Best Blastp hit = gi|120563|sp|P21164|FTHS_MOOTH FORMATE--TETRAHYDROFOLATE LIGASE (FORMYLTETRAHYDROFOLATE SYNTHETASE) (FHS) (FTHFS) gi|98640|pir||A35942 formate--tetrahydrofolate ligase (EC 6.3.4.3) - Clostridium thermaceticum gi|144816|gb|AAA23240.1| (J02911) formyltetrahydrofolate synthetase (FTHFS) (ttg start codon) (EC 6.3.4.3) [Moorella thermoacetica], score 744, E-value 0. | 0.997 |
FolD | MetH2 | TTE1293 | TTE1803 | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Methionine synthase I, cobalamin-binding domain protein; Best Blastp hit = gi|7462040|pir||B72397 5-methyltetrahydrofolate S-homocysteine methyltransferase - Thermotoga maritima (strain MSB8) gi|4980766|gb|AAD35357.1|AE001709_3 (AE001709) 5-methyltetrahydrofolate S-homocysteine methyltransferase [Thermotoga maritima], score 538, E-value 1.00E-151. | 0.757 |
FolD | PurH | TTE1293 | TTE0592 | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); Best Blastp hit = gi|10173247|dbj|BAB04352.1| (AP001509) phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [Bacillus halodurans], score 611, E-value 1.00E-174. | 0.969 |
FolD | PurN | TTE1293 | TTE0591 | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Folate-dependent phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.974 |
FolD | TTE0450 | TTE1293 | TTE0450 | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glutamate formiminotransferase; Best Blastp hit = gi|7462794|pir||D72326 hypothetical protein TM0843 - Thermotoga maritima (strain MSB8) gi|4981376|gb|AAD35925.1|AE001751_5 '(AE001751) formiminotransferase- cyclodeaminase/formiminotetrahydrofolate cyclodeaminase, putative [Thermotoga maritima]', score 343, E-value 2.00E-93. | 0.906 |
FolD | TTE0456 | TTE1293 | TTE0456 | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Methenyl tetrahydrofolate cyclohydrolase; Best Blastp hit = gi|13540921|ref|NP_110609.1| Formiminotransferase cyclodeaminase [Thermoplasma volcanium], score 107, E-value 1.00E-22. | 0.977 |
GcvT | FolD | TTE0296 | TTE1293 | Glycine cleavage system T protein (aminomethyltransferase); The glycine cleavage system catalyzes the degradation of glycine. | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.960 |
GcvT | GlyA | TTE0296 | TTE2130 | Glycine cleavage system T protein (aminomethyltransferase); The glycine cleavage system catalyzes the degradation of glycine. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.998 |
GcvT | MIS1 | TTE0296 | TTE2391 | Glycine cleavage system T protein (aminomethyltransferase); The glycine cleavage system catalyzes the degradation of glycine. | Formyltetrahydrofolate synthetase; Best Blastp hit = gi|120563|sp|P21164|FTHS_MOOTH FORMATE--TETRAHYDROFOLATE LIGASE (FORMYLTETRAHYDROFOLATE SYNTHETASE) (FHS) (FTHFS) gi|98640|pir||A35942 formate--tetrahydrofolate ligase (EC 6.3.4.3) - Clostridium thermaceticum gi|144816|gb|AAA23240.1| (J02911) formyltetrahydrofolate synthetase (FTHFS) (ttg start codon) (EC 6.3.4.3) [Moorella thermoacetica], score 744, E-value 0. | 0.948 |
GcvT | MetH2 | TTE0296 | TTE1803 | Glycine cleavage system T protein (aminomethyltransferase); The glycine cleavage system catalyzes the degradation of glycine. | Methionine synthase I, cobalamin-binding domain protein; Best Blastp hit = gi|7462040|pir||B72397 5-methyltetrahydrofolate S-homocysteine methyltransferase - Thermotoga maritima (strain MSB8) gi|4980766|gb|AAD35357.1|AE001709_3 (AE001709) 5-methyltetrahydrofolate S-homocysteine methyltransferase [Thermotoga maritima], score 538, E-value 1.00E-151. | 0.977 |
GcvT | PurH | TTE0296 | TTE0592 | Glycine cleavage system T protein (aminomethyltransferase); The glycine cleavage system catalyzes the degradation of glycine. | AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); Best Blastp hit = gi|10173247|dbj|BAB04352.1| (AP001509) phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [Bacillus halodurans], score 611, E-value 1.00E-174. | 0.941 |
GcvT | PurN | TTE0296 | TTE0591 | Glycine cleavage system T protein (aminomethyltransferase); The glycine cleavage system catalyzes the degradation of glycine. | Folate-dependent phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.931 |
GcvT | TTE0450 | TTE0296 | TTE0450 | Glycine cleavage system T protein (aminomethyltransferase); The glycine cleavage system catalyzes the degradation of glycine. | Glutamate formiminotransferase; Best Blastp hit = gi|7462794|pir||D72326 hypothetical protein TM0843 - Thermotoga maritima (strain MSB8) gi|4981376|gb|AAD35925.1|AE001751_5 '(AE001751) formiminotransferase- cyclodeaminase/formiminotetrahydrofolate cyclodeaminase, putative [Thermotoga maritima]', score 343, E-value 2.00E-93. | 0.902 |
GcvT | TTE0456 | TTE0296 | TTE0456 | Glycine cleavage system T protein (aminomethyltransferase); The glycine cleavage system catalyzes the degradation of glycine. | Methenyl tetrahydrofolate cyclohydrolase; Best Blastp hit = gi|13540921|ref|NP_110609.1| Formiminotransferase cyclodeaminase [Thermoplasma volcanium], score 107, E-value 1.00E-22. | 0.924 |
GlyA | FolD | TTE2130 | TTE1293 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.989 |
GlyA | GcvT | TTE2130 | TTE0296 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Glycine cleavage system T protein (aminomethyltransferase); The glycine cleavage system catalyzes the degradation of glycine. | 0.998 |
GlyA | MIS1 | TTE2130 | TTE2391 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Formyltetrahydrofolate synthetase; Best Blastp hit = gi|120563|sp|P21164|FTHS_MOOTH FORMATE--TETRAHYDROFOLATE LIGASE (FORMYLTETRAHYDROFOLATE SYNTHETASE) (FHS) (FTHFS) gi|98640|pir||A35942 formate--tetrahydrofolate ligase (EC 6.3.4.3) - Clostridium thermaceticum gi|144816|gb|AAA23240.1| (J02911) formyltetrahydrofolate synthetase (FTHFS) (ttg start codon) (EC 6.3.4.3) [Moorella thermoacetica], score 744, E-value 0. | 0.982 |