STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MIS1Formyltetrahydrofolate synthetase; Best Blastp hit = gi|120563|sp|P21164|FTHS_MOOTH FORMATE--TETRAHYDROFOLATE LIGASE (FORMYLTETRAHYDROFOLATE SYNTHETASE) (FHS) (FTHFS) gi|98640|pir||A35942 formate--tetrahydrofolate ligase (EC 6.3.4.3) - Clostridium thermaceticum gi|144816|gb|AAA23240.1| (J02911) formyltetrahydrofolate synthetase (FTHFS) (ttg start codon) (EC 6.3.4.3) [Moorella thermoacetica], score 744, E-value 0. (555 aa)    
Predicted Functional Partners:
FolD
5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
 
 
 0.997
PurH
AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); Best Blastp hit = gi|10173247|dbj|BAB04352.1| (AP001509) phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [Bacillus halodurans], score 611, E-value 1.00E-174.
  
 0.986
GlyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.982
MetH2
Methionine synthase I, cobalamin-binding domain protein; Best Blastp hit = gi|7462040|pir||B72397 5-methyltetrahydrofolate S-homocysteine methyltransferase - Thermotoga maritima (strain MSB8) gi|4980766|gb|AAD35357.1|AE001709_3 (AE001709) 5-methyltetrahydrofolate S-homocysteine methyltransferase [Thermotoga maritima], score 538, E-value 1.00E-151.
  
 
 0.975
TTE0456
Methenyl tetrahydrofolate cyclohydrolase; Best Blastp hit = gi|13540921|ref|NP_110609.1| Formiminotransferase cyclodeaminase [Thermoplasma volcanium], score 107, E-value 1.00E-22.
    
 0.972
PurN
Folate-dependent phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
  
 0.970
GcvT
Glycine cleavage system T protein (aminomethyltransferase); The glycine cleavage system catalyzes the degradation of glycine.
  
 0.948
TTE0450
Glutamate formiminotransferase; Best Blastp hit = gi|7462794|pir||D72326 hypothetical protein TM0843 - Thermotoga maritima (strain MSB8) gi|4981376|gb|AAD35925.1|AE001751_5 '(AE001751) formiminotransferase- cyclodeaminase/formiminotetrahydrofolate cyclodeaminase, putative [Thermotoga maritima]', score 343, E-value 2.00E-93.
    
  0.931
Icd
Isocitrate dehydrogenases; Best Blastp hit = gi|7431248|pir||H72288 isocitrate dehydrogenase - Thermotoga maritima (strain MSB8) gi|4981696|gb|AAD36224.1|AE001772_3 (AE001772) isocitrate dehydrogenase [Thermotoga maritima], score 536, E-value 1.00E-151; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
 
 
  
 0.893
TTE2390
Conserved hypothetical protein; Best Blastp hit = gi|7434028|pir||H64673 dihydropteroate synthase (EC 2.5.1.15) [similarity] - Helicobacter pylori (strain 26695) gi|2314394|gb|AAD08276.1| (AE000628) dihydropteroate synthase (folP) [Helicobacter pylori 26695], score 52, E-value 2.00E-06.
  
  
 0.813
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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