STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RsbUSerine phosphatase RsbU, regulator of sigma subunit; Best Blastp hit = gi|586018|sp|P37475|SP2E_BACSU STAGE II SPORULATION PROTEIN E gi|2127240|pir||S66094 stage II sporulation protein SpoIIE - Bacillus subtilis gi|467453|dbj|BAA05299.1| (D26185) stage II sporulation [Bacillus subtilis] gi|857493|gb|AAB58073.1| (U26835) SpoIIE [Bacillus subtilis] gi|2632331|emb|CAB11840.1| (Z99104) serine phosphatase [Bacillus subtilis] gi|1588992|prf||2209421A spollE gene [Bacillus subtilis], score 299, E-value 1.00E-79. (785 aa)    
Predicted Functional Partners:
TTE1638
Sporulation specific protein; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family.
  
  
 0.947
TTE2552
pro-sigma-E processing factor spoIIR; Best Blastp hit = gi|730770|sp|P39151|SP2R_BACSU STAGE II SPORULATION PROTEIN R gi|2127223|pir||I40474 pro-sigma-E processing factor spoIIR - Bacillus subtilis gi|556879|emb|CAA86103.1| (Z38002) Unknown [Bacillus subtilis] gi|2636222|emb|CAB15714.1| '(Z99122) alternate gene name: ipc-27d, csfX [Bacillus subtilis]' gi|1095417|prf||2108403B spoIIR gene [Bacillus subtilis], score 120, E-value 1.00E-26.
  
   
 0.899
TTE0170
Transcription regulator of sigma-E/sigma-K-dependent gene spoIIID; Best Blastp hit = gi|134766|sp|P15281|SP3D_BACSU STAGE III SPORULATION PROTEIN D (14 KD TRANSCRIPTION FACTOR) gi|98493|pir||A33472 transcription regulator of sigma-E/sigma-K-dependent gene spoIIID - Bacillus subtilis gi|580763|emb|CAA33541.1| (X15520) transcription factor (AA 1-93) [Bacillus subtilis] gi|580931|emb|CAA36295.1| (X52076) spoIIID protein (AA 1-93) [Bacillus subtilis] gi|1684653|emb|CAB05384.1| (Z82987) SpoIIID [Bacillus subtilis] gi|2636167|emb|CAB15659.1| (Z99122) transcriptional regulator [Bacillus subti [...]
  
   
 0.869
CheY7
CheY-like receiver domains; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
  
  
 0.860
TTE1283
Best Blastp hit = gi|730774|sp|Q01367|S3AA_BACSU STAGE III SPORULATION PROTEIN AA gi|98386|pir||S16622 stage III sporulation protein spoIIIAA - Bacillus subtilis gi|581722|emb|CAA43959.1| (X61962) SpoIIIAA protein [Bacillus subtilis] gi|1000359|gb|AAA76720.1| (U35252) SpoIIIAA [Bacillus subtilis] gi|1303904|dbj|BAA12560.1| (D84432) SpoIIIAA [Bacillus subtilis] gi|2634877|emb|CAB14374.1| (Z99116) spoIIIAA [Bacillus subtilis], score 257, E-value 2.00E-67.
  
   
 0.843
SpoIIAA
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor); Best Blastp hit = gi|10174153|dbj|BAB05255.1| (AP001512) anti-sigma F factor antagonist (stage II sporulation protein AA) [Bacillus halodurans], score 100, E-value 5.00E-21; Belongs to the anti-sigma-factor antagonist family.
  
  
 0.837
RpoD2
DNA-directed RNA polymerase sigma subunits (sigma70/sigma32); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
  
 0.836
RsbW3
Anti-sigma regulatory factor (Ser/Thr protein kinase); Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
  
 0.833
TTE1616
Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
  
   
 0.831
TTE2563
Transcription regulator spoVT; Best Blastp hit = gi|586883|sp|P37554|SP5T_BACSU STAGE V SPORULATION PROTEIN T gi|2126881|pir||S66086 AbrB homolog - Bacillus subtilis gi|7475924|pir||F69716 transcription regulator spoVT - Bacillus subtilis gi|467445|dbj|BAA05291.1| (D26185) similar to AbrB [Bacillus subtilis] gi|2632323|emb|CAB11832.1| (Z99104) transcriptional regulator [Bacillus subtilis], score 201, E-value 5.00E-51.
 
   
 0.827
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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