node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ClpP | GuaB | TTE0625 | TTE0582 | Protease subunit of ATP-dependent Clp proteases; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.591 |
ClpP | SurA2 | TTE0625 | TTE2564 | Protease subunit of ATP-dependent Clp proteases; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Parvulin-like peptidyl-prolyl isomerase; Plays a major role in protein secretion by helping the post- translocational extracellular folding of several secreted proteins. | 0.473 |
DegQ2 | GuaB | TTE2568 | TTE0582 | Trypsin-like serine protease, typically periplasmic, contain C-terminal PDZ domain; Best Blastp hit = gi|6063141|gb|AAF03153.1|AF188296_1 (AF188296) HtrA-like serine protease [Bacillus subtilis], score 225, E-value 8.00E-58. | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.414 |
DegQ2 | Mfd | TTE2568 | TTE2565 | Trypsin-like serine protease, typically periplasmic, contain C-terminal PDZ domain; Best Blastp hit = gi|6063141|gb|AAF03153.1|AF188296_1 (AF188296) HtrA-like serine protease [Bacillus subtilis], score 225, E-value 8.00E-58. | Transcription-repair coupling factor - superfamily II helicase; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.612 |
DegQ2 | Pth | TTE2568 | TTE2567 | Trypsin-like serine protease, typically periplasmic, contain C-terminal PDZ domain; Best Blastp hit = gi|6063141|gb|AAF03153.1|AF188296_1 (AF188296) HtrA-like serine protease [Bacillus subtilis], score 225, E-value 8.00E-58. | Peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. | 0.617 |
DegQ2 | SurA2 | TTE2568 | TTE2564 | Trypsin-like serine protease, typically periplasmic, contain C-terminal PDZ domain; Best Blastp hit = gi|6063141|gb|AAF03153.1|AF188296_1 (AF188296) HtrA-like serine protease [Bacillus subtilis], score 225, E-value 8.00E-58. | Parvulin-like peptidyl-prolyl isomerase; Plays a major role in protein secretion by helping the post- translocational extracellular folding of several secreted proteins. | 0.542 |
DegQ2 | TTE2566 | TTE2568 | TTE2566 | Trypsin-like serine protease, typically periplasmic, contain C-terminal PDZ domain; Best Blastp hit = gi|6063141|gb|AAF03153.1|AF188296_1 (AF188296) HtrA-like serine protease [Bacillus subtilis], score 225, E-value 8.00E-58. | Hypothetical protein. | 0.542 |
GuaB | ClpP | TTE0582 | TTE0625 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Protease subunit of ATP-dependent Clp proteases; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.591 |
GuaB | DegQ2 | TTE0582 | TTE2568 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Trypsin-like serine protease, typically periplasmic, contain C-terminal PDZ domain; Best Blastp hit = gi|6063141|gb|AAF03153.1|AF188296_1 (AF188296) HtrA-like serine protease [Bacillus subtilis], score 225, E-value 8.00E-58. | 0.414 |
GuaB | PorA | TTE0582 | TTE0445 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit; Best Blastp hit = gi|4972241|emb|CAB43935.1| (Y17727) pyruvate ferredoxin oxidoreductase [Clostridium pasteurianum], score 1671, E-value 0; Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family. | 0.663 |
GuaB | Pth | TTE0582 | TTE2567 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. | 0.403 |
GuaB | SurA2 | TTE0582 | TTE2564 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Parvulin-like peptidyl-prolyl isomerase; Plays a major role in protein secretion by helping the post- translocational extracellular folding of several secreted proteins. | 0.598 |
GuaB | YidC | TTE0582 | TTE2799 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Preprotein translocase subunit YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins (By similarity). | 0.529 |
Mfd | DegQ2 | TTE2565 | TTE2568 | Transcription-repair coupling factor - superfamily II helicase; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | Trypsin-like serine protease, typically periplasmic, contain C-terminal PDZ domain; Best Blastp hit = gi|6063141|gb|AAF03153.1|AF188296_1 (AF188296) HtrA-like serine protease [Bacillus subtilis], score 225, E-value 8.00E-58. | 0.612 |
Mfd | Pth | TTE2565 | TTE2567 | Transcription-repair coupling factor - superfamily II helicase; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | Peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. | 0.933 |
Mfd | SurA2 | TTE2565 | TTE2564 | Transcription-repair coupling factor - superfamily II helicase; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | Parvulin-like peptidyl-prolyl isomerase; Plays a major role in protein secretion by helping the post- translocational extracellular folding of several secreted proteins. | 0.732 |
Mfd | TTE2563 | TTE2565 | TTE2563 | Transcription-repair coupling factor - superfamily II helicase; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | Transcription regulator spoVT; Best Blastp hit = gi|586883|sp|P37554|SP5T_BACSU STAGE V SPORULATION PROTEIN T gi|2126881|pir||S66086 AbrB homolog - Bacillus subtilis gi|7475924|pir||F69716 transcription regulator spoVT - Bacillus subtilis gi|467445|dbj|BAA05291.1| (D26185) similar to AbrB [Bacillus subtilis] gi|2632323|emb|CAB11832.1| (Z99104) transcriptional regulator [Bacillus subtilis], score 201, E-value 5.00E-51. | 0.709 |
Mfd | TTE2566 | TTE2565 | TTE2566 | Transcription-repair coupling factor - superfamily II helicase; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | Hypothetical protein. | 0.842 |
PorA | GuaB | TTE0445 | TTE0582 | Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit; Best Blastp hit = gi|4972241|emb|CAB43935.1| (Y17727) pyruvate ferredoxin oxidoreductase [Clostridium pasteurianum], score 1671, E-value 0; Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family. | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.663 |
PorA | SurA2 | TTE0445 | TTE2564 | Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit; Best Blastp hit = gi|4972241|emb|CAB43935.1| (Y17727) pyruvate ferredoxin oxidoreductase [Clostridium pasteurianum], score 1671, E-value 0; Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family. | Parvulin-like peptidyl-prolyl isomerase; Plays a major role in protein secretion by helping the post- translocational extracellular folding of several secreted proteins. | 0.455 |