STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ta0099Probable histidyl-tRNA synthetase; Strong similarity to known protein: Arabidopsis thaliana histidyl-tRNA synthetase mRNA, complete cds; TREMBL:AF020715_1; Belongs to the class-II aminoacyl-tRNA synthetase family. (426 aa)    
Predicted Functional Partners:
Ta1203
Translation initiation factor eIF-2, alpha subunit related protein; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family.
  
 0.923
Ta0330
threonine--tRNA ligase related protein; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).
 
 
 0.910
Ta1147
Probable cysteinyl-tRNA synthetase; Strong similarity to known protein: E. coli cysS gene for cysteinyl-tRNA synthetase; TREMBL:ECCYSSG_1.
 
  
 0.816
Ta0512
Probable tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
 
  
 0.804
Ta1054
DNA gyrase, subunit A (gyrA) related protein; Similarity to known protein: DNA topoisomerase (ATP-hydrolyzing) (EC 5.99.1.3) chain A - Haloferax sp; PIR:S30571.
 
  
 0.782
Ta0777
Similarity to known protein: leucyl-tRNA synthetase (leuS) homolog - Archaeoglobus fulgidus; PIR:F69552; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 0.768
Ta1493
Queuine tRNA-ribosyltransferase related protein; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family.
 
  
 0.766
Ta0281
Similarity to known protein: arginine--tRNA ligase (EC 6.1.1.19) - Corynebacterium glutamicum; PIR1:A49936; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
  
 0.764
Ta1112
Translation initiation factor IF-2 related protein; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity).
 
 
 0.753
Ta0040
valyl-tRNA synthetase related protein; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
  
 
 0.748
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.