node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ta0060 | Ta0090 | gene:9571275 | gene:9571305 | Similarity to known protein: purH bifunctional enzyme - Escherichia coli; PIR:DTECPH. | Probable phosphoribosyl-aminoimidazole synthetase; Strong similarity to known protein: Lactococcus lactis cremoris ClpB chaperone homolog (clpB) and phosphoribosylformylglycinamide cyclo-ligase (pur5) genes, complete cds;and phosphoribosylglycinamide formyltransferase (pur3) gene, partial cds; TREMBL:AF016634_2. | 0.999 |
Ta0060 | Ta0219 | gene:9571275 | gene:9571435 | Similarity to known protein: purH bifunctional enzyme - Escherichia coli; PIR:DTECPH. | Probable inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.984 |
Ta0060 | Ta0390 | gene:9571275 | gene:9571610 | Similarity to known protein: purH bifunctional enzyme - Escherichia coli; PIR:DTECPH. | Probable DNA-directed RNA polymerase chain B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.631 |
Ta0060 | Ta0523 | gene:9571275 | gene:9571741 | Similarity to known protein: purH bifunctional enzyme - Escherichia coli; PIR:DTECPH. | Strong similarity to known protein: adenylosuccinate lyase (EC 4.3.2.2) - Bacillus subtilis; PIR1:WZBSDSFunction: Purine metabolism, Alanine and Aspartate metabolism. | 0.999 |
Ta0060 | Ta0880 | gene:9571275 | gene:9572094 | Similarity to known protein: purH bifunctional enzyme - Escherichia coli; PIR:DTECPH. | Ribokinase related protein; Nucleoside kinase with broad substrate specificity. Catalyzes the phosphorylation of a variety of nucleosides to the corresponding nucleoside 5'-mono-phosphate in the presence of phosphate donors and divalent cations. Displays the most efficient activity with guanosine, followed by inosine, cytidine, and adenosine. Negligible enzymatic activity is detected with thymidine, uridine, and 2-deoxyadenosine. ATP is the most efficient phosphate donor, but can also use GTP and ITP. Shows no sugar kinase activity, since it is unable to phosphorylate ribose, fructose- [...] | 0.940 |
Ta0060 | Ta0944 | gene:9571275 | gene:9572162 | Similarity to known protein: purH bifunctional enzyme - Escherichia coli; PIR:DTECPH. | GMP synthase related protein; Catalyzes the synthesis of GMP from XMP. | 0.762 |
Ta0060 | Ta1242 | gene:9571275 | gene:9572465 | Similarity to known protein: purH bifunctional enzyme - Escherichia coli; PIR:DTECPH. | Probable amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.999 |
Ta0060 | Ta1361 | gene:9571275 | gene:9572588 | Similarity to known protein: purH bifunctional enzyme - Escherichia coli; PIR:DTECPH. | Probable GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.852 |
Ta0060 | Ta1367 | gene:9571275 | gene:9572594 | Similarity to known protein: purH bifunctional enzyme - Escherichia coli; PIR:DTECPH. | Probable adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.989 |
Ta0090 | Ta0060 | gene:9571305 | gene:9571275 | Probable phosphoribosyl-aminoimidazole synthetase; Strong similarity to known protein: Lactococcus lactis cremoris ClpB chaperone homolog (clpB) and phosphoribosylformylglycinamide cyclo-ligase (pur5) genes, complete cds;and phosphoribosylglycinamide formyltransferase (pur3) gene, partial cds; TREMBL:AF016634_2. | Similarity to known protein: purH bifunctional enzyme - Escherichia coli; PIR:DTECPH. | 0.999 |
Ta0090 | Ta0219 | gene:9571305 | gene:9571435 | Probable phosphoribosyl-aminoimidazole synthetase; Strong similarity to known protein: Lactococcus lactis cremoris ClpB chaperone homolog (clpB) and phosphoribosylformylglycinamide cyclo-ligase (pur5) genes, complete cds;and phosphoribosylglycinamide formyltransferase (pur3) gene, partial cds; TREMBL:AF016634_2. | Probable inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.856 |
Ta0090 | Ta0523 | gene:9571305 | gene:9571741 | Probable phosphoribosyl-aminoimidazole synthetase; Strong similarity to known protein: Lactococcus lactis cremoris ClpB chaperone homolog (clpB) and phosphoribosylformylglycinamide cyclo-ligase (pur5) genes, complete cds;and phosphoribosylglycinamide formyltransferase (pur3) gene, partial cds; TREMBL:AF016634_2. | Strong similarity to known protein: adenylosuccinate lyase (EC 4.3.2.2) - Bacillus subtilis; PIR1:WZBSDSFunction: Purine metabolism, Alanine and Aspartate metabolism. | 0.995 |
Ta0090 | Ta0880 | gene:9571305 | gene:9572094 | Probable phosphoribosyl-aminoimidazole synthetase; Strong similarity to known protein: Lactococcus lactis cremoris ClpB chaperone homolog (clpB) and phosphoribosylformylglycinamide cyclo-ligase (pur5) genes, complete cds;and phosphoribosylglycinamide formyltransferase (pur3) gene, partial cds; TREMBL:AF016634_2. | Ribokinase related protein; Nucleoside kinase with broad substrate specificity. Catalyzes the phosphorylation of a variety of nucleosides to the corresponding nucleoside 5'-mono-phosphate in the presence of phosphate donors and divalent cations. Displays the most efficient activity with guanosine, followed by inosine, cytidine, and adenosine. Negligible enzymatic activity is detected with thymidine, uridine, and 2-deoxyadenosine. ATP is the most efficient phosphate donor, but can also use GTP and ITP. Shows no sugar kinase activity, since it is unable to phosphorylate ribose, fructose- [...] | 0.499 |
Ta0090 | Ta0944 | gene:9571305 | gene:9572162 | Probable phosphoribosyl-aminoimidazole synthetase; Strong similarity to known protein: Lactococcus lactis cremoris ClpB chaperone homolog (clpB) and phosphoribosylformylglycinamide cyclo-ligase (pur5) genes, complete cds;and phosphoribosylglycinamide formyltransferase (pur3) gene, partial cds; TREMBL:AF016634_2. | GMP synthase related protein; Catalyzes the synthesis of GMP from XMP. | 0.688 |
Ta0090 | Ta1242 | gene:9571305 | gene:9572465 | Probable phosphoribosyl-aminoimidazole synthetase; Strong similarity to known protein: Lactococcus lactis cremoris ClpB chaperone homolog (clpB) and phosphoribosylformylglycinamide cyclo-ligase (pur5) genes, complete cds;and phosphoribosylglycinamide formyltransferase (pur3) gene, partial cds; TREMBL:AF016634_2. | Probable amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.999 |
Ta0090 | Ta1361 | gene:9571305 | gene:9572588 | Probable phosphoribosyl-aminoimidazole synthetase; Strong similarity to known protein: Lactococcus lactis cremoris ClpB chaperone homolog (clpB) and phosphoribosylformylglycinamide cyclo-ligase (pur5) genes, complete cds;and phosphoribosylglycinamide formyltransferase (pur3) gene, partial cds; TREMBL:AF016634_2. | Probable GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.720 |
Ta0090 | Ta1367 | gene:9571305 | gene:9572594 | Probable phosphoribosyl-aminoimidazole synthetase; Strong similarity to known protein: Lactococcus lactis cremoris ClpB chaperone homolog (clpB) and phosphoribosylformylglycinamide cyclo-ligase (pur5) genes, complete cds;and phosphoribosylglycinamide formyltransferase (pur3) gene, partial cds; TREMBL:AF016634_2. | Probable adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.850 |
Ta0219 | Ta0060 | gene:9571435 | gene:9571275 | Probable inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Similarity to known protein: purH bifunctional enzyme - Escherichia coli; PIR:DTECPH. | 0.984 |
Ta0219 | Ta0090 | gene:9571435 | gene:9571305 | Probable inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Probable phosphoribosyl-aminoimidazole synthetase; Strong similarity to known protein: Lactococcus lactis cremoris ClpB chaperone homolog (clpB) and phosphoribosylformylglycinamide cyclo-ligase (pur5) genes, complete cds;and phosphoribosylglycinamide formyltransferase (pur3) gene, partial cds; TREMBL:AF016634_2. | 0.856 |
Ta0219 | Ta0325 | gene:9571435 | gene:9571543 | Probable inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | HAM1 protein related; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.947 |