STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ta0332Purine-nucleoside phosphorylase related protein; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (261 aa)    
Predicted Functional Partners:
Ta1060
Similarity to known protein: ATRAZINE CHLOROHYDROLASE (EC 3.8.1.-) - Pseudomonas sp. (strain ADP); SWISSPROT:ATZA_PSESDFunction: FIRST STEP IN ATRAZINE DEGRADATION PATHWAY.
  
 
 0.966
Ta0355
Spermidine synthase 2 related protein; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
  
 
 0.941
Ta0333
Conserved hypothetical protein; Strong similarity to unknown protein: mRNA 3'-end processing factor homolog - Archaeoglobus fulgidus; PIR:D69316.
  
    0.938
Ta1212
Translation initiation factor aIF-2B, alpha chain related protein; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
  
  
 0.708
Ta1361
Probable GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
 
 0.648
Ta0880
Ribokinase related protein; Nucleoside kinase with broad substrate specificity. Catalyzes the phosphorylation of a variety of nucleosides to the corresponding nucleoside 5'-mono-phosphate in the presence of phosphate donors and divalent cations. Displays the most efficient activity with guanosine, followed by inosine, cytidine, and adenosine. Negligible enzymatic activity is detected with thymidine, uridine, and 2-deoxyadenosine. ATP is the most efficient phosphate donor, but can also use GTP and ITP. Shows no sugar kinase activity, since it is unable to phosphorylate ribose, fructose- [...]
  
 
 0.646
Ta0469
Probable adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
  
 0.590
Ta0684
Deoxyribose-phosphate aldolase related protein; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
   
 0.575
Ta0568
Similarity to known protein: phosphomannomutase (pmm) homolog - Archaeoglobus fulgidus; PIR:B69307; Belongs to the phosphohexose mutase family.
  
 
 0.556
Ta1351
Purine phosphoribosyltransferase related protein; Similarity to known protein: Thermus flavus askA askB and gpt genes for aspartokinase alpha-2 beta-2 andpurine phosphoribosyltransferase, complete cds; TREMBL:TFASKAB_3.
  
  
 0.537
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
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