STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
Ta0546Conserved hypothetical protein; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids. (258 aa)    
Predicted Functional Partners:
Ta1313
Geranylgeranyl pyrophosphate synthase related protein; Similarity to known protein: probable idsA2 protein - Mycobacterium tuberculosis (strain H37RV); PIR:G70935; Belongs to the FPP/GGPP synthase family.
 
 
 0.970
Ta0545
Conserved hypothetical protein; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
       0.936
Ta0486
Uridylate kinase related protein; Catalyzes the reversible phosphorylation of UMP to UDP.
  
  
 0.870
Ta0393
Conserved hypothetical protein; Participates in transcription termination. Belongs to the NusA family.
  
    0.848
Ta0216
Conserved hypothetical protein; Similarity to unknown protein: probable methyltransferase - Pyrococcus horikoshii; PIR:F71131.
  
    0.787
Ta0570
Conserved hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily.
       0.778
Ta0044
Probable CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
  
    0.715
Ta1190
Strong similarity to known protein: ribosomal protein S2 [validated] - Haloarcula marismortui; PIR:G41715; Belongs to the universal ribosomal protein uS2 family.
  
  
 0.695
Ta1274
Similarity to known protein: STEROL-REGULATORY ELEMENT-BINDING PROTEINS INTRAMEMBRANE PROTEASE(EC 3.4.24.-) (SITE-2 PROTEASE) - Homo sapiens (Human); SWISSPROT:MS2P_HUMANFunction: similar to S2P, that encodes a putative metalloprotease required for intramembrane proteolysis of sterol-regulatory element-binding proteins (SREBPs) at Site-2. SREBPs are membrane-bound transcription factors that activate genes regulating cholesterol metabolism. The active NH2-terminal domains of SREBPs are released from membranes by sequential cleavage at two sites: Site-1, within the lumen of the endoplasm [...]
 
  
 0.693
Ta0436
Similarity to known protein: BIFUNCTIONAL SHORT CHAIN ISOPRENYL DIPHOSPHATE SYNTHASE [INCLUDES:FARNESYL PYROPHOSPHATE SYNTHETASE (EC 2.5.1.1) (FPP SYNTHETASE)(DIMETHYLALLYLTRANSFERASE); GERANYLTRANSTRANSFERASE (EC 2.5.1.10)] - Methanobacterium thermoautotrophicum (strain Marburg / DSM 2133); SWISSPROT:IDSA_METTM.
 
  
 0.667
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.