STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ta0571Strong similarity to known protein: glutamate-1-semialdehyde 2, 1-aminomutase (EC 5.4.3.8) - common tobacco; PIR:S21455; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (426 aa)    
Predicted Functional Partners:
Ta0536
glutamyl-tRNA reductase related protein; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.996
Ta0572
Porphobilinogen deaminase related protein; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
  
 0.996
Ta0955
Probable porphobilinogen synthase; Strong similarity to known protein: DELTA-AMINOLEVULINIC ACID DEHYDRATASE (EC 4.2.1.24) (PORPHOBILINOGENSYNTHASE) (ALAD) (ALADH) - Escherichia coli; SWISSPROT:HEM2_ECOLI; Belongs to the ALAD family.
 
 
 0.996
Ta0573
Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
  
 0.916
Ta0653
S-adenosyl-L-methionine uroporphyrinogen methyltransferase related protein; Similarity to known protein: uroporphyrin-III C-methyltransferase (EC 2.1.1.107) [validated] - Methanobacterium ivanovii; PIR:A42471.
     
 0.823
Ta1277
Thiamine phosphate pyrophosphorylase (yeast THI6) related protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
    
 0.801
Ta0310
Uroporphyrinogen decarboxylase related protein; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
  
 0.724
Ta1508
Probable SA protein; Strong similarity to known protein: Mus musculus SA mRNA, complete cds; TREMBL:AB022340_1.
 
  
 0.711
Ta0311
Ferrochelatase related protein; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
  
  
 0.700
Ta0364
Similarity to known protein: A.thaliana mRNA for aspartate kinase; TREMBL:ATAKLYS1_1.
 
  
 0.666
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.