STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ta0809Probable aldehyde dehydrogenase; NADP-dependent dehydrogenase of the nED (non-phosphorylated Entner-Doudoroff) pathway with highest activity towards glyceraldehydes (e.g. D,L-glyceraldehyde and D-glyceraldehyde), to a lesser extent towards D,L-glyceraldehyde-3-phosphate and glycolaldehyde, but no activity towards aliphatic or aromatic aldehydes. (493 aa)    
Predicted Functional Partners:
Ta1157
Similarity to known protein: DIHYDRODIPICOLINATE SYNTHASE (EC 4.2.1.52) (DHDPS) - Prochlorococcus marinus; SWISSPROT:DAPA_PROMA. Relation: also similar to 2-keto-3-deoxy gluconate aldolase TREMBL:SSO224174_1; Belongs to the DapA family.
 
 
 0.928
Ta0619
Probable 2-keto-3-deoxy gluconate aldolase; Strong similarity to known protein: Sulfolobus solfataricus gene encoding 2-keto-3-deoxy gluconate aldolase; TREMBL:SSO224174_1. Relation: shows also similarity to dihydrodipicolinate synthase (EC 4.2.1.52) dapA - Bacillus subtilis, PIR:E46665.
  
 
 0.927
Ta0453
Glycerate kinase related protein; Similarity to known protein: Methylobacterium extorquens putative glycerate kinase and pyruvate kinase(pykA) genes, complete cds; TREMBLNEW:MEU87316_4.
  
 
 0.914
Ta0810
Strong similarity to known protein: TUNGSTEN-CONTAINING ALDEHYDE FERREDOXIN OXIDOREDUCTASE (EC 1.2.7.-) - Pyrococcus furiosus; SWISSPROT:AOR_PYRFUFunction: involved in aldehyde oxidation.
    
 0.907
Ta0834
Similarity to known protein: TUNGSTEN-CONTAINING ALDEHYDE FERREDOXIN OXIDOREDUCTASE (EC 1.2.7.-) - Pyrococcus furiosus; SWISSPROT:AOR_PYRFU.
    
 0.907
Ta1142
Similarity to known protein: TUNGSTEN-CONTAINING ALDEHYDE FERREDOXIN OXIDOREDUCTASE (EC 1.2.7.-) - Pyrococcus furiosus; SWISSPROT:AOR_PYRFU.
    
 0.907
Ta0300
Similarity to unknown protein: conserved hypothetical protein c0207 - Sulfolobus solfataricus; PIR:S74025.
  
  
 0.672
Ta0880
Ribokinase related protein; Nucleoside kinase with broad substrate specificity. Catalyzes the phosphorylation of a variety of nucleosides to the corresponding nucleoside 5'-mono-phosphate in the presence of phosphate donors and divalent cations. Displays the most efficient activity with guanosine, followed by inosine, cytidine, and adenosine. Negligible enzymatic activity is detected with thymidine, uridine, and 2-deoxyadenosine. ATP is the most efficient phosphate donor, but can also use GTP and ITP. Shows no sugar kinase activity, since it is unable to phosphorylate ribose, fructose- [...]
 
 
 0.592
Ta0806
Similarity to known protein: anthranilate synthase (EC 4.1.3.27) component I - Clostridium thermocellum; PIR:JX0065.
     
 0.582
Ta0808
Similarity to known protein: indole-3-glycerol-phosphate synthase (EC 4.1.1.48) TrpC - Sulfolobus solfataricus; PIR:C40635; Belongs to the TrpC family.
     
 0.582
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.