STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ta0896Similarity to known protein: pyruvate kinase (EC 2.7.1.40) [validated] - Bacillus licheniformis; PIR:JC4220. (544 aa)    
Predicted Functional Partners:
Ta0882
Enolase related protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
 0.992
Ta1419
Conserved hypothetical protein; Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency; Belongs to the PGI/PMI family.
  
 
 0.976
Ta0456
Malate oxidoreductase (malic enzyme) related protein; Similarity to known protein: malate dehydrogenase (oxaloacetate-decarboxylating) (EC 1.1.1.38) - Bacillus stearothermophilus; PIR:DEBSXS.
  
 0.951
Ta0886
Strong similarity to unknown protein: pyruvate, orthophosphate dikinase (EC 2.7.9.1) - Thermotoga maritima (strain MSB8); PIR:F72397Function: Pyruvate metabolism, Carbon ixation.
    
 0.931
Ta0123
Probable phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
  
 
 0.929
Ta0260
Probable pyruvate ferredoxin oxidoreductase, beta subunit; Strong similarity to known protein: 2-oxoacid--ferredoxin oxidoreductase (EC 1.2.7.-) beta chain - Methanobacterium thermoautotrophicum (strain Delta H); PIR:H69170.
  
 0.927
Ta0626
Strong similarity to known protein: PYRUVATE/KETOISOVALERATE OXIDOREDUCTASES COMMON GAMMA SUBUNIT[INCLUDES: PYRUVATE SYNTHASE SUBUNIT PORC (EC 1.2.7.1) (PYRUVATEOXIDOREDUCTASE GAMMA CHAIN) (POR) (PYRUVIC-FERREDOXIN OXIDOREDUCTASEGAMMA SUBUNIT); KETOISOVALERATE OXIDOREDUCTASE SUBUNIT VORC(EC 1.-.-.-) (VOR) (2-OXOISOVALERATE OXIDOREDUCTASE GAMMA CHAIN) (2-OXOISOVALERATE-FERREDOXIN OXIDOREDUCTASE GAMMA SUBUNIT)] - Pyrococcus furiosus; SWISSNEW:PORC_PYRFUFunction: Pyruvate metabolism, Propanoate metabolism, Butanoate metabolism, Reductive carboxylate cycle (CO2 fixation).
   
 0.927
Ta0772
Strong similarity to known protein: 2-oxoacid--ferredoxin oxidoreductase (EC 1.2.7.-) beta chain - Sulfolobus sp. (strain 7); PIR:JC4920.
  
 0.927
Ta0816
Similarity to known protein: pyruvate dehydrogenase (cytochrome) (EC 1.2.2.2) - Escherichia coli; PIR:DEECPCFunction: involved in pyruvate metabolism; Belongs to the TPP enzyme family.
  
 0.927
Ta1437
Strong similarity to known protein: 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) (EC 1.2.4.4) chain E1-beta - Pseudomonas putida; PIR:DEPSEB.
  
 
 0.927
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.