STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ta0898Methylenetetrahydrofolate dehydrogenase (NADP+) related protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (276 aa)    
Predicted Functional Partners:
Ta1478
Probable formate-tetrahydrofolate ligase; Strong similarity to known protein: FORMATE--TETRAHYDROFOLATE LIGASE (EC 6.3.4.3) (FORMYLTETRAHYDROFOLATESYNTHETASE) (FHS) (FTHFS) - Streptococcus mutans; SWISSPROT:FTHS_STRMU.
   
 0.990
Ta0082
Strong similarity to known protein: phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) - Arabidopsis thaliana; PIR:S37105.
 
 0.982
Ta1509
Probable glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 0.978
Ta0060
Similarity to known protein: purH bifunctional enzyme - Escherichia coli; PIR:DTECPH.
  
 0.977
Ta0811
Similarity to known protein: glycine hydroxymethyltransferase (EC 2.1.2.1) - Methanobacterium thermoautotrophicum (strain Marburg); PIR:S62190Function: involved in glycine, serine and threonine metabolism, also involved in vitamin B6 metabolism.
 
 0.968
Ta0010
Strong similarity to known protein: aminomethyltransferase (EC 2.1.2.10) [validated] - Escherichia coli; PIR:A56689Function: Glycine, serine and threonine metabolism, One carbon pool by folate, Nitrogen metabolism.
  
 0.945
Ta0897
Glucose 1-dehydrogenase; Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Is also significantly active with galactose as substrate, but not with mannose or glucose 6-phosphate. Can utilize both NAD(+) and NADP(+) as electron acceptor, with a marked preference for NADP(+). Physiologically, may be involved in the degradation of both glucose and galactose through a non-phosphorylative variant of the Entner-Doudoroff pathway; Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.
  
  
 0.940
Ta1476
Probable glutamate formiminotransferase; Catalyzes the transfer of the formyl group from N- formylglutamate to tetrahydrofolate (THF) to yield 5- formyltetrahydrofolate (5-CHO-THF) and glutamate (Glu). The triglutamate form of 5-CHO-THF (5-CHO-THF-Glu3) can also be used as substrate. It can also catalyzes the transfer of the formimino group from N-formiminoglutamate to tetrahydrofolate (THF) to yield 5- formiminotetrahydrofolate (5-NH=CH-THF) and glutamate (Glu). It can replace YgfA to catalyzes the irreversible ATP-dependent transformation of 5-CHO-THF to form 5,10-methenyltetrahydrof [...]
 
  
 0.931
Ta0309
Similarity to known protein: PHOSPHORIBOSYLAMIDOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (EC 6.3.2.6)(SAICAR SYNTHETASE) - Saccharomyces cerevisiae (Baker's yeast); SWISSPROT:PUR7_YEAST.
  
 
 0.776
Ta1037
Proline dipeptidase related protein; Similarity to known protein: Lactobacillus delbrueckii subsp. bulgaricus pepQ, pepR1 genes; TREMBL:LDBPEPQ_1; Belongs to the peptidase M24B family.
 
   0.770
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.