STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ta0994Gamma-glutamyltransferase related protein; Similarity to known protein: GAMMA-GLUTAMYLTRANSPEPTIDASE PRECURSOR (EC 2.3.2.2) - Pseudomonas sp. (strain A14); SWISSPROT:GGT_PSESPFunction: involved in selenoamino acid metabolism, cyanoamino acid metabolism and glutathione metabolism. (516 aa)    
Predicted Functional Partners:
Ta1498
Probable glutamine synthetase; Strong similarity to known protein: Bacillus subtilis glnR and glnA genes for GlnR protein and glutaminesynthetase, complete cds; TREMBL:BSGLNRA_2.
    
 0.888
Ta0635
Strong similarity to known protein: GLUTAMATE DEHYDROGENASE (EC 1.4.1.3) (GDH) - Thermococcus litoralis; SWISSPROT:DHE3_THELIFunction: generally involved with either ammonia assimilation or glutamate catabolism. ORF_prediction: N-terminus longer than those of trelated proteins, however its codon usage does support a coding function of the first 40 aa, the frequency of rare codons is very low, possible second start only after 35 aa, not altered; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.840
Ta0776
Strong similarity to known protein: GLUTAMATE DEHYDROGENASE (EC 1.4.1.3) (GDH) - Pyrococcus horikoshii; SWISSPROT:DHE3_PYRHO; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.840
Ta0603
Similarity to known protein: aldehyde dehydrogenase (EC 1.2.-.-) - Bacillus stearothermophilus; PIR:I39769.
  
 
 0.830
Ta0460
Endonuclease V related protein; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA (By similarity); In the N-terminal section; belongs to the MGMT family.
       0.813
Ta1318
Phosphoribosylformylglycinamidine synthase I related protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is tho [...]
    
  0.813
Ta0414
Similarity to known protein: GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN (EC 1.4.1.13) (GLUTAMATESYNTHASE BETA SUBUNIT) (NADPH-GOGAT) (GLTS BETA CHAIN) - Escherichia coli; SWISSPROT:GLTD_ECOLI.
    
 0.808
Ta0300
Similarity to unknown protein: conserved hypothetical protein c0207 - Sulfolobus solfataricus; PIR:S74025.
 
  
 0.640
Ta0993
Hypothetical membrane protein.
       0.613
Ta0934
Similarity to known protein: acetylornithine deacetylase (EC 3.5.1.16) - Escherichia coli; PIR:B42377Function: Urea cycle and metabolism of amino groups.
     
 0.566
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.