node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ta0199 | Ta0980 | gene:9571415 | gene:9572198 | Probable TATA-box binding protein (TFIID homolog); General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). | Thermosome, alpha chain; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity. | 0.811 |
Ta0199 | Ta1035 | gene:9571415 | gene:9572256 | Probable TATA-box binding protein (TFIID homolog); General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). | DNA repair protein RAD2 related protein; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision rep [...] | 0.598 |
Ta0199 | Ta1059 | gene:9571415 | gene:9572279 | Probable TATA-box binding protein (TFIID homolog); General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). | Translation initiation factor eIF-5a related protein; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. | 0.595 |
Ta0199 | Ta1087 | gene:9571415 | gene:9572308 | Probable TATA-box binding protein (TFIID homolog); General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). | Probable DnaK-type molecular chaperone; Acts as a chaperone. | 0.504 |
Ta0199 | Ta1276 | gene:9571415 | gene:9572500 | Probable TATA-box binding protein (TFIID homolog); General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). | Thermosome beta chain; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity. | 0.834 |
Ta0199 | Ta1288 | gene:9571415 | gene:9572512 | Probable TATA-box binding protein (TFIID homolog); General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The T.acidophilum proteasome is able to cleave oligopeptides after Tyr, Leu, Phe, and to a lesser extent after Glu and Arg. Thus, displays chymotrypsin-like activity and low level of caspase-like and trypsin- like activities; Belongs to the peptidase T1A family. | 0.576 |
Ta0980 | Ta0199 | gene:9572198 | gene:9571415 | Thermosome, alpha chain; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity. | Probable TATA-box binding protein (TFIID homolog); General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). | 0.811 |
Ta0980 | Ta1035 | gene:9572198 | gene:9572256 | Thermosome, alpha chain; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity. | DNA repair protein RAD2 related protein; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision rep [...] | 0.714 |
Ta0980 | Ta1059 | gene:9572198 | gene:9572279 | Thermosome, alpha chain; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity. | Translation initiation factor eIF-5a related protein; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. | 0.775 |
Ta0980 | Ta1076 | gene:9572198 | gene:9572297 | Thermosome, alpha chain; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity. | Gim, alpha subunit related protein; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity). | 0.760 |
Ta0980 | Ta1086 | gene:9572198 | gene:9572307 | Thermosome, alpha chain; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity. | Heat shock protein GrpE related protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Severa [...] | 0.964 |
Ta0980 | Ta1087 | gene:9572198 | gene:9572308 | Thermosome, alpha chain; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity. | Probable DnaK-type molecular chaperone; Acts as a chaperone. | 0.965 |
Ta0980 | Ta1088 | gene:9572198 | gene:9572309 | Thermosome, alpha chain; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity. | Heat shock protein DnaJ related protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interaction [...] | 0.796 |
Ta0980 | Ta1112 | gene:9572198 | gene:9572333 | Thermosome, alpha chain; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity. | Translation initiation factor IF-2 related protein; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity). | 0.816 |
Ta0980 | Ta1276 | gene:9572198 | gene:9572500 | Thermosome, alpha chain; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity. | Thermosome beta chain; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity. | 0.982 |
Ta0980 | Ta1288 | gene:9572198 | gene:9572512 | Thermosome, alpha chain; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity. | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The T.acidophilum proteasome is able to cleave oligopeptides after Tyr, Leu, Phe, and to a lesser extent after Glu and Arg. Thus, displays chymotrypsin-like activity and low level of caspase-like and trypsin- like activities; Belongs to the peptidase T1A family. | 0.752 |
Ta1035 | Ta0199 | gene:9572256 | gene:9571415 | DNA repair protein RAD2 related protein; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision rep [...] | Probable TATA-box binding protein (TFIID homolog); General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). | 0.598 |
Ta1035 | Ta0980 | gene:9572256 | gene:9572198 | DNA repair protein RAD2 related protein; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision rep [...] | Thermosome, alpha chain; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity. | 0.714 |
Ta1035 | Ta1059 | gene:9572256 | gene:9572279 | DNA repair protein RAD2 related protein; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision rep [...] | Translation initiation factor eIF-5a related protein; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. | 0.587 |
Ta1035 | Ta1086 | gene:9572256 | gene:9572307 | DNA repair protein RAD2 related protein; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision rep [...] | Heat shock protein GrpE related protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Severa [...] | 0.451 |