STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ta1305Hypothetical protein; Catalyzes the phosphorylation of mevalonate (MVA) to yield mevalonate-3-phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3-phosphate rather than mevalonate 5- phosphate. (318 aa)    
Predicted Functional Partners:
Ta0406
Similarity to known protein: hydroxymethylglutaryl-CoA reductase (EC 1.1.1.88) - Pseudomonas sp; PIR:A44756.
  
 
 0.932
Ta0762
2-phosphoglycerate kinase related protein; Phosphorylates mevalonate 3-phosphate to form mevalonate 3,5- bisphosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3-phosphate rather than mevalonate 5- phosphate.
    
 0.917
Ta1455
Conserved hypothetical protein; Strong similarity to unknown protein: acyl carrier protein synthase - Methanococcus jannaschii; PIR:A64493; Belongs to the thiolase-like superfamily. UPF0219 family.
  
 
 0.689
Ta1304
Similarity to unknown protein: hypothetical protein Rv0115 - Mycobacterium tuberculosis (strain H37RV); PIR:F70840.
       0.546
Ta0436
Similarity to known protein: BIFUNCTIONAL SHORT CHAIN ISOPRENYL DIPHOSPHATE SYNTHASE [INCLUDES:FARNESYL PYROPHOSPHATE SYNTHETASE (EC 2.5.1.1) (FPP SYNTHETASE)(DIMETHYLALLYLTRANSFERASE); GERANYLTRANSTRANSFERASE (EC 2.5.1.10)] - Methanobacterium thermoautotrophicum (strain Marburg / DSM 2133); SWISSPROT:IDSA_METTM.
  
 
 0.465
Ta1313
Geranylgeranyl pyrophosphate synthase related protein; Similarity to known protein: probable idsA2 protein - Mycobacterium tuberculosis (strain H37RV); PIR:G70935; Belongs to the FPP/GGPP synthase family.
  
 
 0.465
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.