STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Ta1357Glycine dehydrogenase (decarboxylating) related protein, subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (472 aa)    
Predicted Functional Partners:
Ta0010
Strong similarity to known protein: aminomethyltransferase (EC 2.1.2.10) [validated] - Escherichia coli; PIR:A56689Function: Glycine, serine and threonine metabolism, One carbon pool by folate, Nitrogen metabolism.
 0.999
Ta1358
Glycine dehydrogenase (decarboxylating) related protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
0.999
Ta1366
Probable glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 0.999
Ta1509
Probable glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 
 0.974
Ta0811
Similarity to known protein: glycine hydroxymethyltransferase (EC 2.1.2.1) - Methanobacterium thermoautotrophicum (strain Marburg); PIR:S62190Function: involved in glycine, serine and threonine metabolism, also involved in vitamin B6 metabolism.
 
 
 0.973
Ta1189
Probable glycine C-acetyltransferase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
  
 
 0.934
Ta0208
Similarity to known protein: dihydrolipoamide dehydrogenase (EC 1.8.1.4) - Escherichia coli; PIR:DEECLP.
  
 
 0.928
Ta1435
Similarity to known protein: dihydrolipoamide dehydrogenase (EC 1.8.1.4) - Bacillus subtilis; PIR:E36718.
  
 
 0.928
Ta0635
Strong similarity to known protein: GLUTAMATE DEHYDROGENASE (EC 1.4.1.3) (GDH) - Thermococcus litoralis; SWISSPROT:DHE3_THELIFunction: generally involved with either ammonia assimilation or glutamate catabolism. ORF_prediction: N-terminus longer than those of trelated proteins, however its codon usage does support a coding function of the first 40 aa, the frequency of rare codons is very low, possible second start only after 35 aa, not altered; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 0.867
Ta0776
Strong similarity to known protein: GLUTAMATE DEHYDROGENASE (EC 1.4.1.3) (GDH) - Pyrococcus horikoshii; SWISSPROT:DHE3_PYRHO; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 0.867
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.